Elucidation of multi-directed regulatory mechanism focused on regulation in polycomb genes expression for periodontal cells
| Project/Area Number |
25862049
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontology
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 歯周組織再生 / 間葉系幹細胞 / ポリコーム遺伝子 / micro RNA / HIF-1alpha / 歯周靭帯細胞 |
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| Outline of Final Research Achievements |
In this study, it can be suggested that oxygen tension regulate mesenchymal stem cell (MSC) function via hypoxia inducible factor (HIF)-1α, a group of polycomb genes and micro RNA as the expression of polycomb genes were affected by hypoxic condition and hypoxia-induced micro RNA.
Therefore, it is expected that much more effective periodontal regenerative therapy can be come true by the expression regulation of a group of polycomb genes and micro RNA, which controlled by, mainly, control in oxygen tension.
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Report
(3 results)
Research Products
(1 results)
