| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
We noticed that elevated serum amyloid A (SAA) is an acute inflammation markers in mice was induced periodontal disease were analyzed the effect on arteriosclerosis of SAA.
Expression of arteriosclerosis induced factor VCAM-1, ICAM-1, MCP-1 was significantly increased by SAA in human vascular endothelial cells. And their expression was significantly reduced by the TLR2 neutralizing antibody which is one of SAA receptors. So the TLR2 neutralizing antibody, was injected to easy formation mouse (ApoE deficient mice). The results that TLR2 injected group was decrease of lipid deposition site more than control group. In this experiment, SAA would bind to TLR2 on the endothelial cells and increase the adhesion molecules expressions. We suggest that this is one of the pathways that SAA could accelerate the atherosclerosis.
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