Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Outline of Final Research Achievements |
To reveal the molecular mechanism for periodontitis-induced atherosclerosis, I focused Serum amyloid A (SAA), an acute-phase protein. I investigated how do SAA affect human aortic endothelial cells (HAECs). As a result, SAA induced inflammatory molecules via TLR2, and then SAA also induced adhesion molecules. In addition, only the expression of MYD88 was lower in SAA- stimulated HAECs compared with unstimulated HAECs, it suggested that MyD88- independent pathway via TLR2 could be exist in this cascade. My result suggests that TLR2 may have a critical role to induce adhesion molecules following TLR2 signaling and the leukocyte cascade in SAA-stimulated HAECs. And SAA might be a predictive risk marker for atherosclerosis onset in patients with periodontitis.
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