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Neural mechanisms of swallowing using cortico-muscular coherence, and effective neurorehabilitation training for dysphagia

Research Project

Project/Area Number 25862071
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Social dentistry
Research InstitutionHokkaido University

Principal Investigator

MAEZAWA Hitoshi  北海道大学, 歯学研究科(研究院), 助教 (80567727)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords摂食嚥下 / 舌運動 / 運動野 / コヒーレンス / 脳磁図 / 舌下神経核 / 脳ー筋コヒーレンス / 摂食・嚥下 / 口腔機能 / 感覚運動野 / 体性感覚誘発脳電位 / 三叉神経 / 下顎神経 / 感覚異常 / 神経損傷
Outline of Final Research Achievements

Sophisticated tongue movements are essential to swallowing in humans. These fine movements are regulated by descending motor signals from the cortex to the muscles, and by afferent sensory feedback from the muscles to the cortex. We demonstrated the oscillatory synchronization between cortical activity and muscle activity during isometric tongue protrusions in humans. The synchronization was observed at two frequency bands: the β band at 15-35 Hz and a low-frequency band at 2-10 Hz (Neuroimage 2014; 2016). The synchronization at the β band mainly reflects the motor commands from the motor cortex to the tongue. In contrast, the synchronization at a low-frequency band reflects the proprioceptive afferent feedback from the tongue to the somatosensory cortex. Such bidirectional flow of oscillatory information between the cortex and the tongue may be critical to coordination of sophisticated tongue movements in humans.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (20 results)

All 2016 2015 2014 2013

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Acknowledgement Compliant: 4 results,  Open Access: 3 results) Presentation (11 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Recovery of Impaired Somatosensory Evoked Fields After Improvement of Tongue Sensory Deficits With Neurosurgical Reconstruction.2016

    • Author(s)
      Maezawa H, Tojyo I, Yoshida K, Fujita S.
    • Journal Title

      Journal of Oral and Maxillofacial Surgery

      Volume: 未定 Issue: 7 Pages: 1473-1482

    • DOI

      10.1016/j.joms.2016.01.011

    • NAID

      120005906987

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Cortico-muscular communication for motor control of the tongue in humans: a review2016

    • Author(s)
      Maezawa H
    • Journal Title

      Journal of Oral Biosciences

      Volume: 未定 Issue: 3 Pages: 69-72

    • DOI

      10.1016/j.job.2016.03.001

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Cortico-muscular synchronization by proprioceptive afferents from the tongue muscles during isometric tongue protrusion.2016

    • Author(s)
      Maezawa H, Mima T, Yazawa S, Matsuhashi M, Shiraishi H, Funahashi M
    • Journal Title

      Neuroimage

      Volume: 128 Pages: 284-92

    • DOI

      10.1016/j.neuroimage.2015.12.058

    • NAID

      120005906988

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of stimulus-induced 20-Hz activity for the tongue and hard palate during tongue movement in humans.2016

    • Author(s)
      Maezawa H, Onishi K, Yagyu K, Shiraishi H, Hirai Y, Funahashi M.
    • Journal Title

      Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

      Volume: 127 Issue: 1 Pages: 698-705

    • DOI

      10.1016/j.clinph.2015.06.007

    • NAID

      120005763140

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Presynaptically mediated effects of cholecystokinin-8 on the excitability of area postrema neurons in rat brain slices.2015

    • Author(s)
      Sugeta S, Hirai Y, Maezawa H, Inoue N, Yamazaki Y, Funahashi M
    • Journal Title

      Brain Research

      Volume: 1618 Pages: 83-90

    • DOI

      10.1016/j.brainres.2015.05.018

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Contralateral dominance of corticomuscular coherence for both sides of the tongue during human tongue protrusion : An MEG study.2014

    • Author(s)
      Maezawa H, Mima T, Yazawa S, Matsuhashi M, Shiraishi H, Hirai Y, Funahashi M.
    • Journal Title

      Neuroimage

      Volume: 101C Pages: 245-255

    • DOI

      10.1016/j.neuroimage.2014.07.018

    • NAID

      120005525214

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Somatosensory evoked magnetic fields following tongue and hard palate stimulation on the preferred chewing side.2014

    • Author(s)
      Maezawa, H.,Hirai, Y., Shiraishi, H., Funahashi, M.
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 347 Issue: 1-2 Pages: 288-294

    • DOI

      10.1016/j.jns.2014.10.025

    • NAID

      120005688761

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of lip sensory disturbance using somatosensory evoked magnetic fields2014

    • Author(s)
      Maezawa, H., M. Matsuhashi, K. Yoshida, T. Mima, T. Nagamine and H. Fukuyama
    • Journal Title

      Clin Neurophysiol

      Volume: 125 Issue: 2 Pages: 363-369

    • DOI

      10.1016/j.clinph.2013.07.017

    • NAID

      120005397861

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The modulation of rolandic oscillation induced by digital nerve stimulation and self-paced movement of the finger: A MEG study.2014

    • Author(s)
      Enatsu, R., Nagamine, T., Matsubayashi, J., Maezawa, H., Kikuchi, T., Fukuyama, H., Mikuni, N., Miyamoto, S., & Hashimoto, N.
    • Journal Title

      Journal of Neurological Sciences

      Volume: 337 Issue: 1-2 Pages: 201-211

    • DOI

      10.1016/j.jns.2013.12.011

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] ヒトの等尺性舌運動時における双方向の皮質―筋カップリング:脳磁図による研究2016

    • Author(s)
      前澤 仁志、美馬 達哉、平井 喜幸、久留 和成、舩橋 誠
    • Organizer
      日本生理学会
    • Place of Presentation
      札幌、日本、札幌コンベンションセンター
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] ヒトの等尺性舌突出時における皮質─筋コヒーレンス解析:脳磁図による研究2015

    • Author(s)
      前澤 仁志
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      新潟、日本、朱鷺メッセ(新潟コンベンションセンター)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Corticomuscular synchronization during isometric tongue protrusion in humans2015

    • Author(s)
      Hitoshi Maezawa, Tatsuya Mima, Shogo Yazawa, Masao Matsuhashi, Hideaki Shiraishi, Makoto Funahashi
    • Organizer
      International Society for the Advancement of Clinical Magnetoencephalography meeting
    • Place of Presentation
      ヘルシンキ、フィンランド
    • Year and Date
      2015-06-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Contralateral dominance of corticomuscular coherence for the tongue during human tongue protrusion: An MEG study2014

    • Author(s)
      前澤 仁志、美馬 達哉、矢澤 省吾、 松橋 眞生、白石 秀明、舩橋 誠
    • Organizer
      日本臨床神経生理学会
    • Place of Presentation
      福岡国際会議場 (福岡県・福岡市)
    • Year and Date
      2014-11-19 – 2014-11-21
    • Related Report
      2014 Research-status Report
  • [Presentation] Corticomuscular synchronization during isometric tongue protrusion in humans: A magnetoencephalographic study2014

    • Author(s)
      Hitoshi Maezawa, Tatsuya Mima, Hideaki Shiraishi, Yoshiyuki Hirai, Makoto Funahashi
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      福岡国際会議場 (福岡県・福岡市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] L-ヒスチジン誘発の摂食抑制及び悪心誘発に対するノルアドレナリン作動性神経の関与2014

    • Author(s)
      奥舎 有加、平井 喜幸、前澤 仁志、山崎 裕、舩橋 誠
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      福岡国際会議場 (福岡県・福岡市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 最後野および孤束核のノルアドレナリン作動性ニューロンの悪心・嘔吐誘発への関与2014

    • Author(s)
      平井 喜幸、前澤 仁志、舩橋 誠
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      福岡国際会議場 (福岡県・福岡市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] ヒトの舌突出時における脳磁図―筋電図コヒーレンス解析2014

    • Author(s)
      前澤 仁志,美馬 達哉,矢澤 省吾, 松橋 眞生,白石 秀明,平井 喜幸,舩橋 誠
    • Organizer
      日本生理学会北海道地方会
    • Place of Presentation
      北海道大学 (北海道・札幌市)
    • Year and Date
      2014-08-30
    • Related Report
      2014 Research-status Report
  • [Presentation] Recovery of impaired somatosensory evoked fields by tongue stimulation after oral surgery.2013

    • Author(s)
      Maezawa Hitoshi, Nagamine Takashi, Fujita Shigeyuki, Matsuhashi Masao, Yoshida Kazuya, Matsubayashi Jun, Mima Tatsuya, Funahashi Makoto, Fukuyama Hidenao.
    • Organizer
      International Society for the Advancement of Clinical Magnetoencephalography
    • Place of Presentation
      Sapporo Tokyo Dome Hotel (Sapporo)
    • Related Report
      2013 Research-status Report
  • [Presentation] 体性感覚誘発脳磁場を用いた口唇感覚異常の客観的評価2013

    • Author(s)
      前澤仁志、吉田和也、美馬達哉、平井喜幸、舩橋 誠、長峯 隆、福山秀直.
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      岡山コンベンションセンター (岡山市)
    • Related Report
      2013 Research-status Report
  • [Presentation] ラット最後野ニューロンのシナプス前CCK受容体を介した興奮性調節.2013

    • Author(s)
      菅田真吾、平井喜幸、前澤仁志、舩橋 誠.
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      岡山コンベンションセンター (岡山市)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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