Neural mechanisms of swallowing using cortico-muscular coherence, and effective neurorehabilitation training for dysphagia

• Project/Area Number: 25862071
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Social dentistry
• Research Institution: Hokkaido University
• Principal Investigator: MAEZAWA Hitoshi 北海道大学, 歯学研究科(研究院), 助教 (80567727)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 摂食嚥下 / 舌運動 / 運動野 / コヒーレンス / 脳磁図 / 舌下神経核 / 脳ー筋コヒーレンス / 摂食・嚥下 / 口腔機能 / 感覚運動野 / 体性感覚誘発脳電位 / 三叉神経 / 下顎神経 / 感覚異常 / 神経損傷

Outline of Final Research Achievements

Sophisticated tongue movements are essential to swallowing in humans. These fine movements are regulated by descending motor signals from the cortex to the muscles, and by afferent sensory feedback from the muscles to the cortex. We demonstrated the oscillatory synchronization between cortical activity and muscle activity during isometric tongue protrusions in humans. The synchronization was observed at two frequency bands: the β band at 15-35 Hz and a low-frequency band at 2-10 Hz (Neuroimage 2014; 2016). The synchronization at the β band mainly reflects the motor commands from the motor cortex to the tongue. In contrast, the synchronization at a low-frequency band reflects the proprioceptive afferent feedback from the tongue to the somatosensory cortex. Such bidirectional flow of oscillatory information between the cortex and the tongue may be critical to coordination of sophisticated tongue movements in humans.

Research Products

• [Journal Article] Recovery of impaired somatosensory evoked fields after improvement of tongue sensory deficits with neurosurgical reconstruction. (2016)
  • Author(s): Maezawa H, Tojyo I, Yoshida K, Fujita S.
  • Journal Title: J Oral Maxillofac Surg. Volume: 未定 Pages: 1473-1482
  • DOI: 10.1016/j.joms.2016.01.011
  • NAID: 120005906987
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Cortico-muscular communication for motor control of the tongue in humans: a review. (2016)
  • Author(s): Maezawa H
  • Journal Title: Journal of Oral Biosciences Volume: 未定 Pages: 69-72
  • DOI: 10.1016/j.job.2016.03.001
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Cortico-muscular synchronization by proprioceptive afferents from the tongue muscles during isometric tongue protrusion (2016)
  • Author(s): Maezawa H, Mima T, Yazawa S, Matsuhashi M, Shiraishi H, Funahashi M
  • Journal Title: Neuroimage Volume: 128 Pages: 284-292
  • DOI: 10.1016/j.neuroimage.2015.12.058
  • NAID: 120005906988
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Modulation of stimulus-induced 20-Hz activity for the tongue and hard palate during tongue movement in humans. (2016)
  • Author(s): Maezawa H, Onishi K, Yagyu K, Shiraishi H, Hirai Y, Funahashi M.
  • Journal Title: Clin Neurophysiol. Volume: 127 Pages: 698-705
  • DOI: 10.1016/j.clinph.2015.06.007
  • NAID: 120005763140
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Presynaptically mediated effects of cholecystokinin-8 on the excitability of area postrema neurons in rat brain slices. (2015)
  • Author(s): Sugeta S, Hirai Y, Maezawa H, Inoue N, Yamazaki Y, Funahashi M
  • Journal Title: Sugeta S, Hirai Y, Maezawa H, Inoue N, Yamazaki Y, Funahashi M. Volume: 1618 Pages: 83-90
  • DOI: 10.1016/j.brainres.2015.05.018
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effects of treadmill exercise on the LiCl-induced conditioned taste aversion in rats. (2015)
  • Author(s): Maezawa, H.,Hirai, Y., Shiraishi, H., Funahashi, M.
  • Journal Title: Physiol Behav. Volume: 347 Pages: 288-294
  • DOI: 10.1016/j.jns.2014.10.025
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Contralateral dominance of corticomuscular coherence for both sides of the tongue during human tongue protrusion: an MEG study. (2014)
  • Author(s): Maezawa H, Mima T, Yazawa S, Matsuhashi M, Shiraishi H, Hirai Y, Funahashi M.
  • Journal Title: NeuroImage. Volume: 101C Pages: 245-255
  • DOI: 10.1016/j.neuroimage.2014.07.018
  • NAID: 120005525214
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Evaluation of lip sensory disturbance using somatosensory evoked magnetic fields. (2014)
  • Author(s): Maezawa, H., M. Matsuhashi, K. Yoshida, T. Mima, T. Nagamine and H. Fukuyama
  • Journal Title: Clinical Neurophysiology Volume: 125 Pages: 363-369
  • DOI: 10.1016/j.clinph.2013.07.017
  • NAID: 120005397861
  • Peer Reviewed
• [Journal Article] The modulation of rolandic oscillation induced by digital nerve stimulation and self-paced movement of the finger: a MEG study. (2014)
  • Author(s): Enatsu, R., Nagamine, T., Matsubayashi, J., Maezawa, H., Kikuchi, T., Fukuyama, H., Mikuni, N., Miyamoto, S., & Hashimoto, N.
  • Journal Title: Journal of Neurological science Volume: 337 Pages: 201-211
  • DOI: 10.1016/j.jns.2013.12.011
  • Peer Reviewed
• [Presentation] ヒトの等尺性舌運動時における双方向の皮質―筋カップリング:脳磁図による研究 (2016)
  • Author(s): 前澤 仁志、美馬 達哉、平井 喜幸、久留 和成、舩橋 誠
  • Organizer: 日本生理学会
  • Place of Presentation: 札幌、日本、札幌コンベンションセンター
  • Year and Date: 2016-03-22
• [Presentation] ヒトの等尺性舌突出時における皮質─筋コヒーレンス解析：脳磁図による研究 (2015)
  • Author(s): 前澤 仁志
  • Organizer: 歯科基礎医学会
  • Place of Presentation: 新潟、日本、朱鷺メッセ（新潟コンベンションセンター）
  • Year and Date: 2015-09-11
  • Invited
• [Presentation] Corticomuscular synchronization during isometric tongue protrusion in humans (2015)
  • Author(s): Hitoshi Maezawa, Tatsuya Mima, Shogo Yazawa, Masao Matsuhashi, Hideaki Shiraishi, Makoto Funahashi
  • Organizer: International Society for the Advancement of Clinical Magnetoencephalography meeting
  • Place of Presentation: ヘルシンキ、フィンランド
  • Year and Date: 2015-06-23
  • Int'l Joint Research
• [Presentation] Contralateral dominance of corticomuscular coherence for the tongue during human tongue protrusion: An MEG study (2014)
  • Author(s): 前澤 仁志、美馬 達哉、矢澤 省吾、 松橋 眞生、白石 秀明、舩橋 誠
  • Organizer: 日本臨床神経生理学会
  • Place of Presentation: 福岡国際会議場 （福岡県・福岡市）
  • Year and Date: 2014-11-19 – 2014-11-21
• [Presentation] Corticomuscular synchronization during isometric tongue protrusion in humans: A magnetoencephalographic study (2014)
  • Author(s): Hitoshi Maezawa, Tatsuya Mima, Hideaki Shiraishi, Yoshiyuki Hirai, Makoto Funahashi
  • Organizer: 歯科基礎医学会
  • Place of Presentation: 福岡国際会議場 （福岡県・福岡市）
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] L-ヒスチジン誘発の摂食抑制及び悪心誘発に対するノルアドレナリン作動性神経の関与 (2014)
  • Author(s): 奥舎 有加、平井 喜幸、前澤 仁志、山崎 裕、舩橋 誠
  • Organizer: 歯科基礎医学会
  • Place of Presentation: 福岡国際会議場 （福岡県・福岡市）
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] 最後野および孤束核のノルアドレナリン作動性ニューロンの悪心・嘔吐誘発への関与 (2014)
  • Author(s): 平井 喜幸、前澤 仁志、舩橋 誠
  • Organizer: 歯科基礎医学会
  • Place of Presentation: 福岡国際会議場 （福岡県・福岡市）
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] ヒトの舌突出時における脳磁図―筋電図コヒーレンス解析 (2014)
  • Author(s): 前澤 仁志，美馬 達哉，矢澤 省吾， 松橋 眞生，白石 秀明，平井 喜幸，舩橋 誠
  • Organizer: 日本生理学会北海道地方会
  • Place of Presentation: 北海道大学 （北海道・札幌市）
  • Year and Date: 2014-08-30
• [Presentation] Recovery of impaired somatosensory evoked fields by tongue stimulation after oral surgery. (2013)
  • Author(s): Maezawa Hitoshi, Nagamine Takashi, Fujita Shigeyuki, Matsuhashi Masao, Yoshida Kazuya, Matsubayashi Jun, Mima Tatsuya, Funahashi Makoto, Fukuyama Hidenao.
  • Organizer: International Society for the Advancement of Clinical Magnetoencephalography
  • Place of Presentation: Sapporo Tokyo Dome Hotel (Sapporo)
• [Presentation] 体性感覚誘発脳磁場を用いた口唇感覚異常の客観的評価 (2013)
  • Author(s): 前澤仁志、吉田和也、美馬達哉、平井喜幸、舩橋 誠、長峯 隆、福山秀直.
  • Organizer: 歯科基礎医学会
  • Place of Presentation: 岡山コンベンションセンター （岡山市）
• [Presentation] ラット最後野ニューロンのシナプス前ＣＣＫ受容体を介した興奮性調節. (2013)
  • Author(s): 菅田真吾、平井喜幸、前澤仁志、舩橋 誠.
  • Organizer: 歯科基礎医学会
  • Place of Presentation: 岡山コンベンションセンター （岡山市）