| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Influenza virus neuraminidase (NA) cleaves terminal sialic acid residues and promotes the release of progeny virus from an infected cell by destroying host cell receptors and the virus itself. Previous studies have reported the presence of bacterial NA activity in dental plaque fluid and saliva. In this study, we examined the biological effects of oral bacteria on the releases of influenza. Streptococcus oralis and Streptococcus mitis were found to exhibit NA activity and their culture supernatants promoted the release of influenza virus and cell-to-cell spread of the infection. Furthermore, we demonstrated that NA inhibitor zanamivir suppressed the release of progeny viruses from the infected cells, and interestingly, the viral release was restored upon the addition of culture supernatants of NA-producing oral bacteria.
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