Longitudinal study of pregnant women to elucidate the effect of toxic trace elements on pregnancy, delivery and newborn

• Project/Area Number: 25862205
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Lifelong developmental nursing
• Research Institution: National Defense Medical College (2015); Kobe University (2013-2014)
• Principal Investigator: NISHIOKA Emiko 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, その他部局等, 教授 (70550797)
• Research Collaborator: YOKOYAMA Kazuhito 順天堂大学, 医学部衛生学講座, 教授 ; MATSUKAWA Takehisa 順天堂大学, 医学部衛生学講座, 助教 ; Vigeh Mohsen 独立行政法人労働安全衛生研究所, 有害性評価研究グループ, 研究員 ; MIIDA Takashi 順天堂大学, 医学部臨床検査医学講座, 教授 ; HIRAYAMA Satoshi 順天堂大学, 医学部臨床検査医学講座, 准教授 ; UENO Tsuyoshi 順天堂大学, 医学部臨床検査医学講座, 協力研究員 ; TAKEDA Satoru 順天堂大学, 医学部産婦人科学講座, 教授 ; MAKINO Shintaro 順天堂大学, 医学部産婦人科学講座, 准教授
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 母性・女性看護学 / 妊娠 / 分娩 / 新生児 / 微量元素 / 出生体重 / 胎児発育 / 甲状腺刺激ホルモン / 鉛

Outline of Final Research Achievements

To assess the relationship between birth weight and maternal blood lead levels　(BPb), 386 pregnant women, aged 34.5 ± 4.8 (21-46) years, and their newborns were　surveyed. Maternal BPb concentrations were 0.98 ± 0.55 (0.049 - 3.99), 0.92 ± 0.63 (0.049 - 3.96), and 0.99 ± 0.66 (0.049-3.96) μg/dl at 12, 25 and 36th weeks of gestation, respectively. Gestational ages at the delivery of newborns (197 males and 189 females) were 38.9 ± 1.3 weeks (35-41). In male newborns, significant correlation between birth weight and logBPb at 12th of gestation was observed (rs = -0.145, p<0.05). Results of multiple regression analysis indicated that birth weight was significantly related to log BPb at 12th weeks of gestation, controlling for possible confounding variables. It is thus suggested that low-level exposure to lead at an early stage of gestation could be a risk factor for low birth weight in male fetus.

Research Products

• [Journal Article] Relationship between maternal thyroid-stimulating hormone(TSH) elevation during pregnancy and low birth weight: A longitudinal study of apparently healthy urban Japanese women at very low risk. (2015)
  • Author(s): Emiko Nishioka et al.
  • Journal Title: Early Human development Volume: 91 Issue: 3 Pages: 181-185
  • DOI: 10.1016/j.earlhumdev.2014.12.014
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Evidence that birth weight is decreased by maternal lead levels below 5μg/dl in male newborns. (2014)
  • Author(s): Nishioka E., Yokoyama K., Matsukawa T., Vigeh M., Hirayama S., Ueno T., Miida T., Makino S., Takeda S.
  • Journal Title: Reproductive Toxicology Volume: 47 Pages: 21-26
  • DOI: 10.1016/j.reprotox.2014.05.007
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 血中マンガンの増加が妊娠高血圧を誘導する (2016)
  • Author(s): ヴィージェモーセン, 西岡笑子,松川岳久,大谷勝己, 横山和仁
  • Organizer: 第74回日本衛生学会総会
  • Place of Presentation: 日本
  • Year and Date: 2016-05-11
• [Presentation] 妊婦の運動習慣と分娩アウトカムとの関連 (2016)
  • Author(s): 西岡笑子
  • Organizer: 第30回日本助産学会学術集会
  • Place of Presentation: 日本
  • Year and Date: 2016-03-19
• [Presentation] 妊娠時の血中ALPアイソザイム(胎盤由来ALP4型)活性の変動 (2015)
  • Author(s): 上野 剛, 平山 哲, 田村 昌大, 笹本 健太, 長尾 侑紀, 小野塚 麻里, 杉原 匡美, 西岡 笑子, 牧野 真太郎, 安部 勝美, 竹田 省, 三井田 孝
  • Organizer: 第62回臨床検査医学会
  • Place of Presentation: 日本
  • Year and Date: 2015-11-19
• [Presentation] 妊娠時の糖代謝指標に及ぼす貧血および甲状腺機能の影響 (2015)
  • Author(s): 平山 哲, 上野 剛, 笹本 健太, 長尾 侑紀, 田村 昌大, 山 安希子, 小野塚 麻里, 杉原 匡美, 西岡 笑子, 牧野 真太郎, 竹田 省, 三井田 孝
  • Organizer: 第62回臨床検査医学会
  • Place of Presentation: 日本
  • Year and Date: 2015-11-19
• [Presentation] Low-level lead exposure during pregnancy and birth weight (2015)
  • Author(s): ヴィージェモーセン, 西岡笑子,松川岳久,大谷勝己, 横山和仁
  • Organizer: 第74回日本公衆衛生学会総会
  • Place of Presentation: 日本
  • Year and Date: 2015-11-04
• [Presentation] Prenatal exposure to low-level lead may reduce birth weight (2015)
  • Author(s): Mohsen Vigeh, Emiko Nishioka, Takehisa Matsukawa, Katsumi Ohtani, Shigeki Koda, Kazuhito Yokoyama
  • Organizer: 51 st Congress of the European Societies of Toxicology Bridging Sciences for Safety Euro Tox.
  • Place of Presentation: ポルトガル
  • Year and Date: 2015-09-13
  • Int'l Joint Research
• [Presentation] Relationship between physical activity during pregnancy and mood changes after delivery in Japanese women (2015)
  • Author(s): Nishioka Emiko, Yokoyama Kazuhito, Matsukawa Takehisa,
  • Organizer: The 2nd Congress, International Academy of Sportology
  • Place of Presentation: 日本
  • Year and Date: 2015-09-12
  • Int'l Joint Research