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Molecular association of Death receptor 6 with peripheral lymphocyte activation

Research Project

Project/Area Number 25870017
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General medical chemistry
Experimental pathology
Research InstitutionHokkaido University

Principal Investigator

Fujikura Daisuke  北海道大学, 人獣共通感染症リサーチセンター, 特任助教 (70547794)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsdeath receptor 6 / T細胞 / DR6
Outline of Final Research Achievements

Activation of peripheral lymphocytes is a critical step for host protection against infections and tumors. Since ‘high’ activation of the cells induces severe systemic immunological disorders, the activation should be accurately regulated. The regulation depends on the association between several surface molecules that are expressed on the cells. Death receptor 6 (DR6) is an orphan receptor that expresses on peripheral T lymphocytes. However, the detail of the molecule remains unclear. Here, we generated a novel anti-DR6 specific antibody that has an activity for the receptor cross-linking. Using this antibody, we found the induction of DR6 expressing T cells in the disease progression of systemic lupus erythematosus animal model. Administration of the antibody suppressed the activation of T cells. Importantly, the administration also delayed the disease progression of the animal model. These findings indicate that DR6 might be a novel therapeutic target for immunological disorders.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (9 results)

All 2015 2014 2013

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results) Presentation (2 results) (of which Int'l Joint Research: 1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] The Interaction between TIM-1 and NPC1 is important for the cellular entry of Ebola virus2015

    • Author(s)
      Kuroda M, Fujikura D, Nanbo A, Marzi A, Noyori O, Kajihara M, Maruyama J, Matsuno K, Miyamoto H, Yoshida R, Feldmann H, Takada A
    • Journal Title

      J. Virol.

      Volume: 印刷中 Issue: 12 Pages: 6481-6493

    • DOI

      10.1128/jvi.03156-14

    • NAID

      120005621883

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] <i>Bacillus cereus</i> from the environment is genetically related to the highly pathogenic <i>B. cereus</i> in Zambia2015

    • Author(s)
      Ogawa H, Ohnuma M, Squarre D, Mweene AS, Ezaki T, Fujikura D, Ohnishi N, Thomas Y, Hang'ombe BM, Higashi H.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 77 Issue: 8 Pages: 993-995

    • DOI

      10.1292/jvms.15-0059

    • NAID

      130005094678

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A novel multiplex PCR discriminates Bacillus anthracis and its genetically related strains from other Bacillus cereus group species2015

    • Author(s)
      Ogawa H., Fujikura D., Ohnuma M., Ohnishi N., Hang'ombe B.M., Mimuro M., Ezaki T., Mweene A.S., Higashi H
    • Journal Title

      PLoS One

      Volume: 10 Issue: 3 Pages: e0122004-e0122004

    • DOI

      10.1371/journal.pone.0122004

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A polymorphism of the TIM-1 IgV domain: Implications for the susceptibility to filovirus infection.2014

    • Author(s)
      Makoto Kuroda, Daisuke Fujikura, Osamu Noyori, Masahiro Kajihara, Junki Maruyama, Hiroko Miyamoto, Reiko Yoshida, Ayato Takada.
    • Journal Title

      Biochemical and biophysical research communications

      Volume: 455 Issue: 3-4 Pages: 223-228

    • DOI

      10.1016/j.bbrc.2014.10.144

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genome Sequence of a Bacillus anthracis Outbreak Strain from Zambia, 2011.2014

    • Author(s)
      Ohnishi N, Maruyama F, Ogawa H, Kachi H, Yamada S, Fujikura D, Nakagawa I, Hang'ombe MB, Thomas Y, Mweene AS, Higashi H.
    • Journal Title

      Genome Announc.

      Volume: 2(2)

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Heat Shock Protein 70 Modulates Influenza A Virus Polymerase Activity2013

    • Author(s)
      Manzoor R, Kuroda K, Yoshida R, Tsuda Y, Fujikura D, Miyamoto H, Kajihara M, Kida H, Takada A
    • Journal Title

      J. Biol. Chem.

      Volume: 289 Issue: 11 Pages: 7599-7614

    • DOI

      10.1074/jbc.m113.507798

    • NAID

      120005460233

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Death receptor 6 is involved in a regulatory mechanism for follicular helper T cell.2015

    • Author(s)
      Daisuke FUJIKURA
    • Organizer
      The 14th Awaji International Forum on Infection and Immunity, September 8-11, 2015 Awaji Oral and Poster presentation
    • Place of Presentation
      Awaji Yumebutai International Conference Center, Awaji, Hyogo, Japan
    • Year and Date
      2015-09-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of a Novel Anthrax Vaccine Antigen and Analysis of Molecular Pathogenicity in Bacillus anthracis Infection.2014

    • Author(s)
      Daisuke FUJIKURA, Memi Mutoh, Naomi Ohnishi, Miyuki Ohnuma, Hirohito Ogawa, Bernard M. Hang’Ombe, Aaron S. Mweene and Hideaki Higashi
    • Organizer
      Asian-African Research Forum on Emerging and Reemerging Infections 2014
    • Place of Presentation
      Sendai international center, sendai, Japan
    • Related Report
      2013 Research-status Report
  • [Patent(Industrial Property Rights)] 免疫制御剤2013

    • Inventor(s)
      藤倉大輔、上出利光
    • Industrial Property Rights Holder
      藤倉大輔、上出利光
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-11-20
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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