Structural analysis of HLA-G6 isoform bound to LILRB2 receptor
Project/Area Number |
25870019
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Structural biochemistry
Functional biochemistry
|
Research Institution | Hokkaido University |
Principal Investigator |
KUROKI KIMIKO 北海道大学, 薬学研究科(研究院), 助教 (90553313)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | HLA-G6 / 電子顕微鏡解析 / 表面プラスモン共鳴法 / CIAマウス / LILR / PIR-B / 抗炎症効果 / 相互作用解析 |
Outline of Final Research Achievements |
I performed structural and functional analysis of the HLA-G6 isoform. Electron microscopy technique revealed the three-dimensional structure of HLA-G2/G6 homodimer which resemble HLA class I and HLA class II heterodimer molecule. In addition, I examined the function of HLA-G6 isoform in CIA mice. HLA-G6 specifically bound to the mouse receptor, PIR-B, and showed significant anti-inflammatory effects in vivo.
|
Report
(3 results)
Research Products
(3 results)