The role of erythropoietin in the production and secretion of neurohypophyseal hormone
| Project/Area Number |
25870035
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Integrative animal science
Animal production science
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| Research Institution | Iwate University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | エリスロポイエチン / 低酸素 / 下垂体ホルモン / 神経内分泌 / エリスロポイエチン受容体 / 体液ホメオスタシス / 神経 |
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| Outline of Final Research Achievements |
This study revealed that continuous hypoxic stimulation suppressed the water intake and food intake without a decrease in urinary volume. This result indicates that hypoxia disorders the homeostasis of body fluid balance and the regulation of neurohypophyseal hormone. In addition to the constant mRNA expression of erythropoietin（EPO), known as a hypoxia-responsive hematopoietic cytokine, in the neurohypophysis, immunohistochemical analyses detected the expression of EPO receptor in the areas around the inferior hypophyseal artery, where are rich in axon terminals and pituicytes.
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Report
(4 results)
Research Products
(2 results)
