Elucidation of the molecular basis related to the nicotinic acetylcholine receptor involved in the development of oral cancer

• Project/Area Number: 25870047
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathobiological dentistry/Dental radiology; Surgical dentistry
• Research Institution: Tohoku University
• Principal Investigator: NISHIOKA TAKASHI 東北大学, 歯学研究科(研究院), 助教 (50641875)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: ニコチン / 口腔がん / 喫煙 / がん

Outline of Final Research Achievements

The tobacco is one of the major risk factor for oral cancer. Nicotine is a main component of tobacco, but has not been demonstrated to affect directly carcinogenesis yet. In the present study, nicotine promotes phosphorylation of Epidermal Growth Factor Receptor (EGFR) signal, which pathways associated with mitogenic for cells, also the involvement of nicotinic acetylcholine receptor α7 was suggested.

Research Products

• [Journal Article] Insulin-like growth factor I inhibits alveolar bone loss following tooth extraction in rats. (2015)
  • Author(s): Akira Kumasaka, Masahiro Iikubo, Takashi Nishioka, Ikuho Kojima, Noriaki Shoji, Maya Sakamoto, Takashi Sasano.
  • Journal Title: Clin Implant Dent Relat Res. Volume: 印刷中 Issue: 6 Pages: 1174-1179
  • DOI: 10.1111/cid.12227
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Nicotine increases the resistance of lung cancer to cisplatin through enhancing Bcl-2 stability (2014)
  • Author(s): Nishioka T, L-Y Luo, Shen L, He H, Mariyannis A, Dai W, Chen C.
  • Journal Title: British Journal of Cancer Volume: 110(7) Issue: 7 Pages: 1785-1792
  • DOI: 10.1038/bjc.2014.78
  • Peer Reviewed / Open Access
• [Presentation] Nicotine exposure induces the proliferation of oral cancer cell (2015)
  • Author(s): Takashi Nishioka, Hiroyuki Tada
  • Organizer: 第57回歯科基礎医学会学術大会
  • Place of Presentation: 新潟
  • Year and Date: 2015-09-11
• [Presentation] Nicotine exposure increases the resistance of lung and breast cancer cells to cisplatin through enhancing Bcl-2 stability and promotes activation EGFR signal in oral cancer cells (2014)
  • Author(s): Takashi Nishioka, Ling-Yu Luo, Ling Shen, Huan He, Alexandros Mariyannis, Takashi Sasano, Changyan Chen
  • Organizer: 19th World Congress on Advances in Oncology and 17th International Symposium on Molecular Medicine
  • Place of Presentation: Athens, Greece
  • Year and Date: 2014-10-09 – 2014-10-11
• [Presentation] Nicotine Exposure Increases the Resistance of Cancer Cells to Cisplatin through Enhancing Bcl-2 Stability (2014)
  • Author(s): Takashi Nishioka, Ling-Yu Luo, Ling Shen, Huan He, Alexandros Mariyannis, Changyan Chen
  • Organizer: Thirteenth Scientific Symposium of the Flight Attendant Medical Research Institute
  • Place of Presentation: Miami, USA
  • Year and Date: 2014-05-05 – 2014-05-07
• [Presentation] Sensitization of epithelial growth factor receptors by nicotine exposure may explore oral cancer (2014)
  • Author(s): Takashi Nishioka, Takashi Sasano
  • Organizer: Innovative Research for Biosis-Abiosis Intelligent Interface Symposium
  • Place of Presentation: 仙台
• [Presentation] CT画像にみられる根管充填剤による歯根破折様アーチファクトについて (2013)
  • Author(s): 飯久保 正弘、西岡 貴志、小林 馨、有地 榮一郎、笹野 高嗣
  • Organizer: 第138回日本歯科保存学会2013年度春季学術大会
  • Place of Presentation: 福岡