Elucidation of the molecular basis related to the nicotinic acetylcholine receptor involved in the development of oral cancer
| Project/Area Number |
25870047
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
Surgical dentistry
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|---|
| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ニコチン / 口腔がん / 喫煙 / がん |
|---|
| Outline of Final Research Achievements |
The tobacco is one of the major risk factor for oral cancer. Nicotine is a main component of tobacco, but has not been demonstrated to affect directly carcinogenesis yet. In the present study, nicotine promotes phosphorylation of Epidermal Growth Factor Receptor (EGFR) signal, which pathways associated with mitogenic for cells, also the involvement of nicotinic acetylcholine receptor α7 was suggested.
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Report
(4 results)
Research Products
(7 results)
