Lung regeneration from iPS by using Nrf2 activator

• Project/Area Number: 25870071
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General medical chemistry; Experimental pathology
• Research Institution: National Cancer Center Japan (2014); Tohoku University (2013)
• Principal Investigator: SATOH Hironori 独立行政法人国立がん研究センター, 研究所, 特別研究員 (90407479)
• Co-Investigator(Renkei-kenkyūsha): MORITA Masanobu 東北大学, 大学院医学系研究科・医化学分野, 助教 (10519094) ; MORIGUCHI Takashi 東北大学, 大学院医学系研究科・医化学分野, 講師 (10447253)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 肺再生 / Nrf2-Keap1 / Nrf2－Keap1 / 肺上皮細胞分化

Outline of Final Research Achievements

The field of lung development lags behind other tissues because of the complex tissue structure. The fact that Nrf2 could contribute to activation of lung developmental genes made us to analyze the relationship between Nrf2 (anti-oxidative stress gene) and lung development. In vivo lung regeneration experiment revealed that Nrf2 plays important roles in lung development. Given this, we next conducted in vitro studies using mouse pluripotent stem cells. Our results indicate that Nrf2 participates in lung development. Further studies are needed to apply this result to clinical use.

Research Products

• [Journal Article] Biallelic DICER1 mutations in sporadic pleuropulmonary blastoma (2018)
  • Author(s): Sakai, E., Nakayama, M., Oshima, H., Kouyama, Y., Niida, A., Fujii, S., Ochiai, A., Nakayama, K. I., Mimori, K., Suzuki, Y., Hong, C. P., Ock, C. Y., Kim, S. J. and Oshima, M.
  • Journal Title: Cancer Research Volume: in press Pages: 1283-1295
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant