Development of powerful genome-wide gene-gene and gene-environment interaction analysis
| Project/Area Number |
25870074
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Statistical science
Human genetics
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| Research Institution | Kurume University (2015)
Tohoku University (2013-2014) |
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Principal Investigator |
Ueki Masao 久留米大学, バイオ統計センター, 准教授 (10515860)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 遺伝的相互作用解析 / ゲノムワイド関連解析 / 高次元回帰モデル / ゲノムワイド遺伝子×遺伝子相互作用 |
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| Outline of Final Research Achievements |
World-wide genome-wide association studies (GWASs) using single nucleotide polymorphisms (SNPs) have revealed that SNPs explain small portion of variability of human phenotypes, so-called the missing heritability problem. Current standard method which tests each SNP one at a time may miss contributions by gene-gene or gene-environment interactions. However, statistical methods for those hypotheses are still underdeveloped. In this project, a new statistical testing method is developed. It allows to vary the degrees of freedom for test statistics according to the observed cell frequencies. Simulation studies confirmed that a practically adequate statistical power is achieved.
In addition, for genetic prediction problem, new sparse modeling method, smooth-threshold multivariate genetic prediction (STMGP), is developed. It is very rapid even in application to large-scale data such as whole-genome sequencing data, and is shown to have higher prediction accuracy.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] A mutation of COX6A1 causes a recessive axonal or mixed form of Charcot-Marie-Tooth disease.2014
Author(s)
Tamiya G, Makino S, Hayashi M, Abe A, Numakura C, Ueki M, Tanaka A, Ito C, Toshimori K, Ogawa N, Terashima T, Maegawa H, Yanagisawa D, Tooyama I, Tada M, Onodera O, Hayasaka K.
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Journal Title
Am J Hum Genet.
Volume: 95
Issue: 3
Pages: 294-300
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A pollen coat-inducible autoinhibited Ca^<2+>-ATPase expressed in stigmatic papilla cells is required for compatible pollination in the Brassicaceae2014
Author(s)
Iwano, M., Igarashi, M., Tarutani, Y., Kaothien-Nakayama, P., Nakayama, H., Moriyama, H., Yakabe, R., Entani, T., Shimosato-Asano, H., Ueki, M., Tamiya, G., and Takayama, S
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Journal Title
Plant Cell
Volume: 26 (2)
Issue: 2
Pages: 636-649
DOI
Related Report
Peer Reviewed
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[Presentation] 超高次元スパース回帰法によるゲノムデータ解析2016
Author(s)
植木優夫, 嶋村海人, 川野秀一, 小西貞則, 田宮元
Organizer
岡山大学IPSR × 九州大学IMI × 理研CSRS シンポジウム 生命データ科学による新たな社会的価値の創造 ～医療、農業、環境分野における役割と作物設計への応用
Place of Presentation
理化学研究所 横浜キャンパス (神奈川)
Year and Date
2016-02-23
Related Report
Invited
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