| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Outline of Final Research Achievements |
To elucidate the physiological roles of Prx4, we have analyzed the cultured cells overexpressed Prx4 and Prx4-knockout mice, and obtained following results. (1) We have identified some proteins which might interact with Prx4 or Prx4t. (2) Prx4 might localize to platelet membrane, which suggests Prx4 might be involved in redox remodeling of membrane proteins. (3) We have established Prx4;SOD1 double knockout mice to elucidate roles of Prx4 under oxidative stress in vivo. The double knockout mice had serious hepatic disorder from infant, suggesting pivotal roles of Prx4 in protection against oxidative injury. (4) Overexpressed Prx4t localized in cytoplasm mainly and expressed antioxidant activity in cultured cells.
|
