| Project/Area Number |
25870078
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Polymer chemistry
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Research Collaborator |
TANAKA Masaru 山形大学, 大学院理工学研究科, 教授 (00322850)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 生分解性ポリマー / 抗血栓性 / 細胞接着性 / 機能性ポリマー / バイオマテリアル / 水和 / 開環重合 / 有機分子触媒 |
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| Outline of Final Research Achievements |
This study has yielded aliphatic polycarbonates with an ether side chain demonstrating the selective cell adhesive property where little platelets adhere but endothelial cells and smooth muscle cells were adsorbed well. The polycarbonates were also found to be degradable in the presence of lipase. Moreover, a new synthetic route to the cyclic carbonate monomers with functional side chain has been established in the process of developing the new polycarbonates. The antithrombotic polycarbonates can be applied to decreasing hemolytic property of a cationic antimicrobial polycarbonate. These findings will be exploited for further developments of medical devices that require biodegradability, blood compatibility, and cell adhesive property.
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