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Elucidation of the mechanisms of a new arthritis inhibitory molecule

Research Project

Project/Area Number 25870091
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Collagenous pathology/Allergology
Immunology
Research InstitutionUniversity of Tsukuba

Principal Investigator

INOUE ASUKA  筑波大学, 医学医療系, 助教 (80636522)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords関節リウマチ / 炎症性サイトカイン / ケモカイン / 好中球 / 細胞遊走 / TIARP / マクロファージ / 滑膜細胞 / サイトカイン
Outline of Final Research Achievements

Recently, We found that TIARP functions as a negative regulator in autoimmune arthritis, although the molecular mechanism of TIARP-expressing cells in arthritis remains uncertain. The purpose of this study is to elucidate the functional role of TIARP in the pathogenesis of arthritis. The severity of arthritis in TIARP-/- mice was markedly exacerbated, and the recruitment of neutrophil into the joint was significantly enhanced. CXCR1/2 expression was significantly higher in TIARP-/- neutrophil, and the recruitment capacity was enhanced to the ligand of CXCL2. Serum-transferred arthritis in TIARP-/- mice was attenuated by the blockade of IL-6R signaling, and recruitment of neutriphil into the joint of TIARP-/- mice was suppressed. These results suggested that TIARP might down-regulate the production of CXCL2 and the expression of CXCR1/2, resulting in the protective ability of neutrophil migration in arthritic joints, probably via the inhibition of IL-6 signaling.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (13 results)

All 2015 2014 2013 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results) Presentation (9 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Specific overexpression of TNFAIP9 in CD14+ CD16- monocytes in patients with rheumatoid arthritis- Comparative analysis with TNFAIP3-2015

    • Author(s)
      Takai C, Matsumoto I, Inoue A, Umeda N, Tanaka Y, Kurashima Y, Wada Y, Narita I, Sumida T.
    • Journal Title

      Clinical Experimenta Immunology

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Regulatory roles of tumor necrosis factor alpha-induced proteins (TNFAIP) 3 and 9 in arthritis.2014

    • Author(s)
      Matsumoto I, Inoue A, Takai C, Umeda N, Tanaka Y, Kurashima Y, Sumida T.
    • Journal Title

      Clinical Immunology

      Volume: -

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] TIARP suppresses the migration of neutrophils via CXCR1/2-CXCL2 pathway in autoimmune arthritis2014

    • Author(s)
      Inoue A, Matsumoto I, Umeda N, Tanaka Y, Kurashima Y, Kawaguchi H, Takahashi S, Sumida T
    • Organizer
      日本免疫学会
    • Place of Presentation
      京都 (京都)
    • Year and Date
      2014-12-10 – 2014-12-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] TIARP suppress migration of neutrophils into joints via down-regulation of CXCL2/CXCR2 pathway in autoimmune arthritis2014

    • Author(s)
      Inoue A, Matsumoto I, Umeda N, Tanaka Y, Takai C, Kurashima Y, Takahashi S, Sumida T
    • Organizer
      The European League Against Rheumatism
    • Place of Presentation
      フランス (パリ)
    • Year and Date
      2014-06-11 – 2014-06-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] TIARPはCXCL2/CXCR2発現抑制による好中球遊走阻害を介して関節炎を制御する2014

    • Author(s)
      井上明日香、松本 功、梅田直人、田中勇希、高井千夏、倉島悠子、高橋 智、住田孝之
    • Organizer
      日本リウマチ学会
    • Place of Presentation
      東京 (品川)
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] TIARP suppresses the migration of neutrophils in arthritis via the reduced CXCL2/CXCR2 expression.2014

    • Author(s)
      Inoue A, Matsumoto I, Umeda N, Tanaka Y, Takai C, Kurashima Y, Takahashi S, Sumida T
    • Organizer
      日本リウマチ学会
    • Place of Presentation
      東京 (品川)
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] TIARP suppresses the migration of neutrophils in arthritis via the reduced CXCL2/CXCR2 expression.2014

    • Author(s)
      Inoue A, Matsumoto I, Umeda N, Tanaka Y, Takai C, Kurashima Y, Takahashi S, Sumida T.
    • Organizer
      日本リウマチ学会
    • Place of Presentation
      東京(品川)
    • Related Report
      2013 Research-status Report
  • [Presentation] TIARPはCXCL2/CXCR2発現抑制による好中球遊走阻害を介して関節炎を制御する2014

    • Author(s)
      井上明日香、松本功、梅田直人、田中勇希、高井千夏、倉島悠子、高橋智、住田孝之
    • Organizer
      日本リウマチ学会
    • Place of Presentation
      東京(品川)
    • Related Report
      2013 Research-status Report
  • [Presentation] TIARP suppresses migration of neutrophils into joints via down-regulation of CXCL2 /CXCR2 pathway in autoimmune arthritis2014

    • Author(s)
      Inoue A, Matsumoto I, Umeda N, Tanaka Y, Takai C, Kurashima Y, Takahashi S, Sumida T.
    • Organizer
      The European League Against Rheumatism
    • Place of Presentation
      フランス(パリ)
    • Related Report
      2013 Research-status Report
  • [Presentation] TNFα-induced adipose-related protein (TIARP) functions as a negative regulator of inflammatory process in arthritis2013

    • Author(s)
      Inoue A, Matsumoto I, Umeda N, Takai C, Tanaka Y, Takahashi S, Sumida T.
    • Organizer
      International Congress of Immunology
    • Place of Presentation
      イタリア(ミラノ)
    • Related Report
      2013 Research-status Report
  • [Presentation] TIARP suppresses the migration of neutrophils and the proliferation of fibroblast-like synoviocytes via regulation of CXCL2 /CXCR2 pathway2013

    • Author(s)
      Inoue A, Matsumoto I, Umeda N, Tanaka Y, Takai C, Kurashima Y, Takahashi S, Sumida T.
    • Organizer
      日本免疫学会
    • Place of Presentation
      千葉(幕張)
    • Related Report
      2013 Research-status Report
  • [Book] リウマチ科2013

    • Author(s)
      井上明日香、松本功、住田孝之
    • Total Pages
      166
    • Publisher
      科学評論社
    • Related Report
      2013 Research-status Report
  • [Remarks] 筑波大学医学医療系内科(膠原病・リウマチ・アレルギー) HP

    • URL

      http://www.md.tsukuba.ac.jp/clinical-med/rheumatology/

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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