| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Interstitial pneumonia (IP) is a chronic progressive interstitial lung disease associated with high mortality and poor prognosis. However, the pathogenesis of IP remains to be elucidated. The goal of this study is to clarify the role of γδNKT (=CD161+ Vδ1+ γδT) cells in systemic sclerosis (SSc) patients with IP. The proportion of gammadelta NKT cells was significantly higher in SSc than healthy controls (HC), and correlated negatively with serum KL-6 levels in IP-positive SSc patients. γδNKT cells in IP-positive SSc patients showed higher production of CCL3 and lower production of IFN-γ than that in HC. Culture supernatant derived from IP-positive SSc patients promoted fibroblast proliferation, whereas that from HC did not. These finding suggest that γδNKT cells may play a regulatory role in the pathogenesis of IP in SSc patients, via IFN-γ. production.
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