| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
We performed first clinical trial for the sustained-release lidocaine sheet (SRLS) in patients. This randomized, single-blind controlled study for 100 outpatient men and women undergoing tooth extraction of the mandibular horizontal impacted wisdom tooth evaluated the efficacy, safety and appropriately administrated dose of the SRLS. We filled their extraction socket with the SRLS to compare their results with the non-administrated group and the control group. A hundred mg-administrated group of the SRLS clinically had therapeutic potential for pain after the tooth extraction although there were not the significant differences between the groups. We didn’t recognize clear side effects and blood concentration rise of lidocaine attributable to the SRLS and was able to demonstrate the safety.
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