Development of high-sensitive mitochondrial stress reporter for in vivo ROS-damage imaging
Project/Area Number |
25870118
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Integrative animal science
Chemical biology
|
Research Institution | Gunma University |
Principal Investigator |
OIKAWA Daisuke 群馬大学, 生体調節研究所, 助教 (20455330)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 活性酸素 / 炎症シグナル / IL-1β / 酸化ストレスレポーター / in vivoイメージング |
Outline of Final Research Achievements |
ROS (reactive oxygen species) is a mitochondrial by-product, interfering with various kinds of biomolecule function. In this study, we developed novel reporter systems detecting mitochondrial stress status or inflammatory damage, and evaluated ROS-mediated damage at cellular level or in animal model.
|
Report
(3 results)
Research Products
(12 results)