| Project/Area Number |
25870128
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Natural medicines
Biomolecular chemistry
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| Research Institution | University of Toyama (2014)
Chiba University (2013) |
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Principal Investigator |
TOUME Kazufumi 富山大学, 和漢医薬学総合研究所, 准教授 (80563981)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 天然物化学 / ケミカルバイオロジー / Wntシグナル / シグナル伝達 / 薬学 / ウィント / Xylocarpus granatum / Calotropis gigantea / β-catenin / 放線菌 / Ricinus communis / calotropin / xylogranin B |
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| Outline of Final Research Achievements |
In this study, we focused on the Wnt signaling pathway. The Wnt signaling plays pivotal roles not only in various aspects of cell biology and adult tissue homeostasis, but also in various diseases, including cancer. During our screening study targeting Wnt signal, we examined a number of plant and actinomycetes extracts using a cell-based luciferase assay system. As a result, we have isolated and identified a number of bioactive natural compounds that inhibit or enhance Wnt signaling. Molecular-biology investigation of these active compounds revealed that they have various and interesting mode of action.
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