Difference of adipocyte function between superficial and deep subcutaneous fat tissue

Research Project

Project/Area Number	25870138
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Plastic surgery Metabolomics
Research Institution	Chiba University
Principal Investigator	KUBOTA Yoshitaka 千葉大学, 医学部附属病院, 講師 (10375735)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000) Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	脂肪移植 / 皮下脂肪 / エピジェネティクス / 脂肪組織
Outline of Final Research Achievements	Subcutaneous fat tissue is frequently used as a donor site of fat or adipocyte grafting. Subcutaneous fat tissue is anatomically separated into two layers by superficial fascia. Superficial fat tissue and deep fat tissue have different function basing on different anatomical structure. The difference in adipocyte function, however, between two layers is still unclear. Our result showed that cell survivability of adipocyte of superficial layer is superior to that of deep layer. Adipocyte differentiation potential is superior in superficial adipocyte compared to deep adipocyte. The difference in epigenetic modification can be one of the causes creating different cell function between two layers.