• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Granger causality analysis of neuronal information flow in the associative memory circuit of the macaque inferotemporal cortex

Research Project

Project/Area Number 25870142
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurophysiology / General neuroscience
Brain biometrics
Research InstitutionNational Institute of Radiological Sciences (2015)
The University of Tokyo (2013-2014)

Principal Investigator

Hirabayashi Toshiyuki  国立研究開発法人放射線医学総合研究所, 分子イメージング研究センター, 主任研究員 (60376423)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords霊長類 / 側頭葉 / 視覚表象 / 多細胞同時記録 / 局所神経回路 / 縦型多点電極 / Granger因果性 / 下部側頭葉 / 対連合記憶
Outline of Final Research Achievements

In primates, neural representations of visual objects are hierarchically constructed along the ventral visual pathway. In this pathway, neural coding of a “novel” feature of visual objects is thought to emerge and become prevalent at a single cortical area as a result of processing in the area. We tested the possibility that a feature representation prevalent in a given cortical area emerges in the microcircuit of a hierarchically prior cortical area as a small number of prototypes and then becomes prevalent in the subsequent area. We recorded activities of multiple single neurons in each of hierarchically sequential areas TE and 36 of macaque temporal cortex and found the predicted convergent microcircuit for object-object association in the lower-order area TE. Associative codes were then built up over time in the microcircuit of the higher-order area 36. These results suggest a computational principle underlying sequentially elaborated object representations across cortical areas.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (23 results)

All 2016 2015 2014 2013 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Acknowledgement Compliant: 4 results,  Open Access: 3 results) Presentation (16 results) (of which Int'l Joint Research: 4 results,  Invited: 13 results) Remarks (2 results)

  • [Journal Article] op-down regulation of laminar circuit via inter-area signal for successful object memory recall in monkey temporal cortex.2015

    • Author(s)
      Takeda, M., Koyano, W.K., Hirabayashi, T., Adachi, Y. and Miyashita,Y.
    • Journal Title

      Neuron

      Volume: 印刷中 Issue: 3 Pages: 840-852

    • DOI

      10.1016/j.neuron.2015.03.047

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Distinct neuronal interactions in anterior inferotemporal areas of macaque monkeys during retrieval of object association memory.2014

    • Author(s)
      Hirabayashi, T., Tamura, K., Takeuchi, D., Takeda, M., Koyano, W.K., and Miyashita, Y.
    • Journal Title

      J. Neurosci.

      Volume: 34 Issue: 28 Pages: 9377-9388

    • DOI

      10.1523/jneurosci.0600-14.2014

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Computational principles of microcircuits for visual object processing in the macaque temporal cortex.2014

    • Author(s)
      Hirabayashi, T. and Miyashita, Y.
    • Journal Title

      Trends in Neurosci.

      Volume: 37 Issue: 3 Pages: 178-187

    • DOI

      10.1016/j.tins.2014.01.002

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] サル側頭葉における物体の視覚表象及び記憶想起を司る神経回路の動作とその計算原理2014

    • Author(s)
      平林 敏行
    • Journal Title

      Clinical Neuroscience

      Volume: 32 Pages: 459-461

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Microcircuits for hierarchical elaboration of object coding across primate temporal areas.2013

    • Author(s)
      Hirabayashi T, Takeuchi D, Tamura K, Miyashita Y.
    • Journal Title

      Science

      Volume: 341 Issue: 6142 Pages: 191-195

    • DOI

      10.1126/science.1236927

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 視覚長期記憶の表象・想起を司る側頭葉の局所回路機構2016

    • Author(s)
      平林 敏行
    • Organizer
      京都大学霊長類研究所共同利用研究会 「霊長類脳科学の新しい展開とゲノム科学との融合」
    • Place of Presentation
      京都大学霊長類研究所、犬山
    • Year and Date
      2016-03-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Microcircuit operation for hierarchical coding of object association across inferotemporal areas in macaques.2016

    • Author(s)
      Hirabayashi, T.,Tamura, K., Takeuchi, D., Takeda, M., Koyano, KW., Miyashita, Y.
    • Organizer
      International Symposium on Adaptive Circuit Shift 2016
    • Place of Presentation
      Doshisha University, Kyoto, Japan.
    • Year and Date
      2016-03-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 視覚長期記憶の表象・想起を司るサル側頭葉の神経回路機構2016

    • Author(s)
      平林 敏行
    • Organizer
      生理学研究所 所長招聘セミナー
    • Place of Presentation
      生理学研究所、岡崎
    • Year and Date
      2016-02-08
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Microcircuit mechanisms for representation and retrieval of associative object memory in macaque temporal cortex2015

    • Author(s)
      Hirabayashi, T.
    • Organizer
      International Symposium on Object Vision in Human, Monkey, and Machine
    • Place of Presentation
      The University of Electro-Communications, Tokyo, Japan
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Microcircuit operation for representation and retrieval of object memory in the macaque temporal cortex2015

    • Author(s)
      Hirabayashi, T.
    • Organizer
      Symposium on Memory and Mind, Tohoku Forum for Creativity Thematic Program 2015
    • Place of Presentation
      Tohoku University, Sendai, Japan
    • Year and Date
      2015-09-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 物体の表象・想起を司るサル側頭葉神経回路の計算原理2015

    • Author(s)
      平林 敏行
    • Organizer
      研究戦略ワークショップ Strategy for Neuroscience
    • Place of Presentation
      玉川大学、東京
    • Year and Date
      2015-09-15
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Towards understanding the circuit mechanisms underpinning conscious retrieval of object memory in macaques2015

    • Author(s)
      Hirabayashi, T.
    • Organizer
      6th BRI Symposium in Niigata: Neural mechanisms of brain functions that require awareness
    • Place of Presentation
      Niigata University, Niigata, Japan
    • Year and Date
      2015-07-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 下部側頭葉における物体の表象と記憶想起を司る局所回路の計算原理2015

    • Author(s)
      平林 敏行
    • Organizer
      ワークショップ「マカクザルの神経科学の将来展望」
    • Place of Presentation
      東京医科歯科大学、東京
    • Year and Date
      2015-04-16
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Microcircuits for hierarchical coding of object-object association across inferotemporal areas of macaques2014

    • Author(s)
      Toshiyuki Hirabayashi, Keita Tamura, Daigo Takeuchi, Masaki Takeda, Kenji W. Koyano, Yasushi Miyashita
    • Organizer
      Neuroscience 2014
    • Place of Presentation
      Walter E. Washington Convention Center, DC, USA
    • Year and Date
      2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] サル下部側頭葉における物体の表象と記憶想起を司る局所回路の計算原理2014

    • Author(s)
      平林 敏行
    • Organizer
      記憶回路研究会
    • Place of Presentation
      生理学研究所(愛知県)
    • Year and Date
      2014-10-08
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 見る、憶える、思い出す:大脳皮質ネットワークにおける知覚と記憶の神経メカニズム2014

    • Author(s)
      平林 敏行
    • Organizer
      第17回自然科学研究機構シンポジウム
    • Place of Presentation
      学術総合センター 一橋講堂(東京都)
    • Year and Date
      2014-09-23
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] マカクザル下部側頭葉における物体の表象及び記憶想起を司る局所回路の計算原理2014

    • Author(s)
      平林 敏行
    • Organizer
      第37回 日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2014-09-13
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Microcircuit operation for representation and memory retrieval of objects in macaque temporal cortex2014

    • Author(s)
      Toshiyuki Hirabayashi
    • Organizer
      Collaborations in Neuroscience Symposium
    • Place of Presentation
      Max Planck Florida Institute for Neuroscience, FL, USA
    • Year and Date
      2014-05-10
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] サル下部側頭葉における物体の表象と記憶想起を司る 局所神経回路内の情報伝達と計算原理

    • Author(s)
      平林 敏行
    • Organizer
      平成25年度 生理学研究所研究会 グローバルネットワークによる 脳情報処理
    • Place of Presentation
      生理学研究所
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Computational principles of microcircuit operations for representation and memory retrieval of objects in macaque temporal cortex

    • Author(s)
      平林 敏行
    • Organizer
      第91回 日本生理学会大会
    • Place of Presentation
      鹿児島大学 郡元キャンパス
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Directional signal flow between different classes of memory neurons during retrieval of object association memory in macaque inferior temporal cortex

    • Author(s)
      T. HIRABAYASHI, D. TAKEUCHI1, K. TAMURA, M. TAKEDA, K. W. KOYANO, Y. MIYASHITA
    • Organizer
      Society for Neuroscience 2013 Annual Meeting
    • Place of Presentation
      San Diego Convention Center
    • Related Report
      2013 Research-status Report
  • [Remarks] 脳内の外界情報データベースが作られる仕組みを解明 ―従来の定説を覆す発見―

    • URL

      http://www.jst.go.jp/pr/announce/20130712-2/index.html

    • Related Report
      2013 Research-status Report
  • [Remarks] 脳内の外界情報データベースが作られる仕組みを解明

    • URL

      http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/new-organizational-principle-of-brains-internal-representation-of-external-world/

    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi