Progesterone receptor signaling contributing to parturition and preterm labor
Project/Area Number |
25870150
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Developmental biology
Obstetrics and gynecology
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Research Institution | The University of Tokyo |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | 黄体ホルモン / プロゲステロン受容体 / 分娩 / 早産 / mTOR / マウスモデル / プロゲステロン / 転写調節 / 妊娠 / p53 / 細胞老化 / ラパマイシン |
Outline of Final Research Achievements |
More than 15 million babies are born preterm each year. A better understanding of prematurity is necessary to prevent it effectively. This study revealed that a mild inflammation induced by LPS absolutely causes preterm birth and neonatal deaths in the uterine p53-deleted mouse model, which naturally exhibits approximately 50% incidence of spontaneous preterm delivery due to cellular senescence and prostaglandin induction in the uterus, and these impairments of parturition are markedly rescued by the combination treatment with an mTOR inhibitor rapamycin and progesterone. Our findings suggest that the combined treatment with low doses of rapamycin and progesterone help to reduce the incidence of preterm birth in its high-risk women.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] MicroRNA-200a locally attenuates progesterone signaling in the cervix, preventing embryo implantation.2014
Author(s)
Hirofumi Haraguchi, Tomoko Saito-Fujita, Yasushi Hirota, Mahiro Egashira, Leona Matsumoto, Mitsunori Matsuo, Takehiro Hiraoka, Kaori Koga, Naoko Yamauchi, Masashi Fukayama, Amanda Bartos, Jeeyeon Cha, Sudhansu K. Dey, Tomoyuki Fujii, Yutaka Osuga.
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Journal Title
Mol Endocrinol.
Volume: 28(7)
Issue: 7
Pages: 1108-17
DOI
Related Report
Peer Reviewed
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