| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Outline of Final Research Achievements |
More than 15 million babies are born preterm each year. A better understanding of prematurity is necessary to prevent it effectively. This study revealed that a mild inflammation induced by LPS absolutely causes preterm birth and neonatal deaths in the uterine p53-deleted mouse model, which naturally exhibits approximately 50% incidence of spontaneous preterm delivery due to cellular senescence and prostaglandin induction in the uterus, and these impairments of parturition are markedly rescued by the combination treatment with an mTOR inhibitor rapamycin and progesterone. Our findings suggest that the combined treatment with low doses of rapamycin and progesterone help to reduce the incidence of preterm birth in its high-risk women.
|
