A better understanding of liver environmental factors on hematogenous metastasis.

Research Project

Project/Area Number	25870157
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Pathological medical chemistry Experimental pathology
Research Institution	The University of Tokyo
Principal Investigator	SAIJOU Eiko 東京大学, 分子細胞生物学研究所, 技術専門職員 (60376647)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000) Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	転移 / がん / 肝臓
Outline of Final Research Achievements	Liver is known as frequently hematogenous metastatic organ. To perform a detailed analysis of liver immune cells, colon cancer cell line Colon26 was transplanted subcutaneously into Balb/c mice. As a result of this transplantation, Ly6G positive neutophil migration was observed prior to liver metastasis of cancer cells. A quantitative RT-PCR experiment shows that significant over expression of chemokine KC in the liver. Liver metastasis was reduced by subcutaneous cancer transplant by using via spleen metastasis model. Immuno-depletion of neutrophil significantly enhances liver metastasis by using via spleen metastasis model. These results indicate that neutrophil plays inhibitory role on colon cancer liver metastasis.

Report

(4 results)