A better understanding of liver environmental factors on hematogenous metastasis.
Project/Area Number |
25870157
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Pathological medical chemistry
Experimental pathology
|
Research Institution | The University of Tokyo |
Principal Investigator |
SAIJOU Eiko 東京大学, 分子細胞生物学研究所, 技術専門職員 (60376647)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 転移 / がん / 肝臓 |
Outline of Final Research Achievements |
Liver is known as frequently hematogenous metastatic organ. To perform a detailed analysis of liver immune cells, colon cancer cell line Colon26 was transplanted subcutaneously into Balb/c mice. As a result of this transplantation, Ly6G positive neutophil migration was observed prior to liver metastasis of cancer cells. A quantitative RT-PCR experiment shows that significant over expression of chemokine KC in the liver. Liver metastasis was reduced by subcutaneous cancer transplant by using via spleen metastasis model. Immuno-depletion of neutrophil significantly enhances liver metastasis by using via spleen metastasis model. These results indicate that neutrophil plays inhibitory role on colon cancer liver metastasis.
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Report
(4 results)
Research Products
(3 results)