| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Gastrointestinal syndrome (GIS) is an acute illness that occurs owing to collapse of intestinal epithelium upon exposure to high amounts of ionizing radiation in nuclear accident or cancer treatment. In this research, we identified that mice deficient in the innate immune receptor Toll-like receptor 3 (TLR3) show substantial resistance to GIS and that an inhibitor of TLR3-RNA binding also ameliorates GIS, suggesting the critical role of TLR3 in the pathogenesis of GIS. We also revealed that, TLR3 induces extensive cell death in small intestinal crypt following the crypt cell death initially induced by irradiation, aggravating destruction of intestinal epithelium. These findings will provide new therapeutic strategies targeting innate immunity for the prevention of GIS.
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