| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
To clarify the associations between the self-evaluated pain status and, skin temprature and two pain biomarker candidate in exudate from venous leg ulcer (VLU) for establishment of an objective pain evaluation. Each participant with VLU self-evaluated their pain status at each examination using the numerical rating scale and the short-form McGill Pain Questionnaire 2. The NGF and S100A8/A9 concentrations in the VLU exudate were measured by enzyme-linked immunosorbent assay. The association between each pain status and, skin temprature and the two standardized protein concentrations was evaluated. Thirteen participants were analyzed. The pain intensity of the high temperature group was significantly higher than the normal temperature group. The standardized NGF concentration was negatively correlated with continuous, intermittent, and neuropathic pain. The standardized S100A8/A9 concentration was positively correlated with present pain intensity.
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