Basic studies for the development of bone and periodontal regeneration system using small molecule compounds
| Project/Area Number |
25870188
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
Bioorganic chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
YONEZAWA Takayuki 東京大学, 工学(系)研究科(研究院), 特任助教 (20410665)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 歯周病 / 骨芽細胞 / 低分子化合物 / 骨形成 |
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| Outline of Final Research Achievements |
To develop strategies for bone-periodontal tissue regeneration using small-molecule compounds, the mode of action of harmine, which is an activator compound of osteoblast differentiation, was investigated. As a result, we found that BMP, Wnt and Hedgehog pathways are involved in the action of harmine on osteoblast differentiation.
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Report
(3 results)
Research Products
(11 results)
