| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Protein-protein interaction networks are useful resources for investigating gene functions and potential drug targets. In this project, we mainly conducted two studies. ①By using genome-wide data of protein-protein interactions, we developed a computational framework to infer potential drug-target genes. Then, we used the framework and inferred potential novel therapeutic targets for Alzheimer's disease, rheumatoid arthritis, and several cancerous diseases. ②We investigated differences and similarities in the structure of protein-protein interaction networks among various species. In order to investigate potential evolutionary mechanisms that can explain the differences and similarities, we conducted comparative genome analyses and computer simulations that use network growth model based on gene duplications.
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