Pain control for chronic pain patients - for tailor-made medicine-

• Project/Area Number: 25870204
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry; Anesthesiology
• Research Institution: Meikai University (2015); Tokyo Medical and Dental University (2013-2014)
• Principal Investigator: Oono Yuka 明海大学, 歯学部, 准教授 (70451961)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: CPM / DNIC / 慢性疼痛患者 / 定量的疼痛評価 / 疼痛コントロール / 定量的熱刺激装置 / 定量的CPM評価 / 疼痛治療法開発

Outline of Final Research Achievements

Conditioned pain modulation (CPM), which is a kind of endogenous pain modulatory mechanisms, is impaired in chronic pain patients, though healthy subjects shows CPM effects. Thus, CPM could be applied for pain control in chronic pain patients as tailor-made medicine.
To establish tailor-made medicine, quantitative evaluation of CPM is needed. For the quantitative evaluation of CPM, a quantitative pressure algometer and a quantitative heat pain stimulator are developed.
It is shown that the quantitative pressure algometer and the quantitative heat pain stimulator are sufficient for a quantitative evaluation of CPM. The study results show that the developed method could be applied for pain control in chronic pain patients as tailor-made medicine.

Research Products

• [Journal Article] Williams症候群の全身麻酔下歯科治療 における周術期管理の1症例 (2016)
  • Author(s): 鈴木佐知子，黒田翔太，上杉典子，今村敏克，髙木沙央理，大野由夏，牧野兼三，長坂浩，小長谷光
  • Journal Title: 日本歯科麻酔学会雑誌 Volume: 44 Pages: 201-203
  • Peer Reviewed
• [Journal Article] Somatosensory assessment and conditioned pain modulation in temporomandibular disorders pain patients (2015)
  • Author(s): Kothari SF, Baad-Hansen L, Oono Y, Svensson P.
  • Journal Title: Pain Volume: 156 Issue: 12 Pages: 2545-55
  • DOI: 10.1097/j.pain.0000000000000325
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Conditioned pain modulation in temporomandibular disorders (TMD) pain patients. (2014)
  • Author(s): Oono Y, Wang K, Baad-Hansen L, Futarmal S, Kohase H, Svensson P, Arendt-Nielsen L.
  • Journal Title: Exp Brain Res. Volume: 232(10) Issue: 10 Pages: 3111-9
  • DOI: 10.1007/s00221-014-3997-7
  • Peer Reviewed
• [Journal Article] 院内にて心室細動による心肺停止後に蘇生しえた1例 (2014)
  • Author(s): 大野由夏, 小長谷光, 市川怜那, 田草川裕子, 深山治久.
  • Journal Title: 日本歯科麻酔学会雑誌 Volume: 42 Pages: 208-212
  • Peer Reviewed
• [Journal Article] Thermal application modulates orofacial somatosensory perception in healthy men and women. (2013)
  • Author(s): Oono Y, Wang K, Atis ES, Arendt-Nielsen L.
  • Journal Title: Clin Neurophysiol Volume: 124 Issue: 3 Pages: 581-588
  • DOI: 10.1016/j.clinph.2012.08.025
  • Peer Reviewed
• [Journal Article] Effect of conditioned pain modulation on trigeminal somatosensory function evaluated by quantitative sensory testing. (2013)
  • Author(s): Oono Y, Baad-Hansen L, Wang K, Arendt-Nielsen L, Svensson P.
  • Journal Title: Pain Volume: 154 Issue: 12 Pages: 2684-90
  • DOI: 10.1016/j.pain.2013.07.049
  • Peer Reviewed
• [Presentation] Williams症候群の全身麻酔下歯科治療の周術期管理の1症例 (2015)
  • Author(s): 上杉 典子, 鈴木 佐知子, 大上 沙央理, 今村 敏克, 牧野 兼三, 大野 由夏, 新井 友理, 龍田 恒康, 嶋田 淳, 長坂 浩, 清水 良昭, 野露 紘子, 小長谷 光
  • Organizer: 第32回 日本障害者歯科学会総会および学術大会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-11-06
• [Presentation] 新たに開発した定量的熱刺激装置 (2015)
  • Author(s): 今村 敏克, 上杉 典子, 竹内 菊子, 星島 宏, 西澤 秀哉, 内田 茂則, 山西 優一郎, 小林 克江, 鈴木 佐知子, 黒田 翔太, 大野 由夏, 大上 沙央理, 長坂 浩, 長谷川 彰彦, 小長谷 光
  • Organizer: 第43回日本歯科麻酔学会総会･学術集会
  • Place of Presentation: 東京
  • Year and Date: 2015-10-30
• [Presentation] Conditioned pain modulation in healthy volunteers evaluated with a new custom-made quantitative cold pain stimulator. (2015)
  • Author(s): Oono Y, Imamura T, Ogami S, Hasegawa A, Nagasaka H, Wang K, Arendt-Nielsen L, Kohase H.
  • Organizer: 9th Congress of the European Federation of IASP Chapters (EFIC)
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2015-09-02
  • Int'l Joint Research
• [Presentation] 新しく開発した圧痛覚閾値測定用アルゴメーターの信頼性 (2015)
  • Author(s): 内田茂則、鈴木佐知子、大野由夏、大上沙央理、小長谷光
  • Organizer: 日本麻酔科学会 第62回学術集会
  • Place of Presentation: 神戸市
  • Year and Date: 2015-05-28 – 2015-05-30
• [Presentation] あらたに開発した定量的熱刺激装置を用いたCPM評価 (2015)
  • Author(s): 今村敏克、大野由夏、大上沙央理、長坂浩、小長谷光
  • Organizer: 日本麻酔科学会 第62回学術集会
  • Place of Presentation: 神戸市
  • Year and Date: 2015-05-28 – 2015-05-30
• [Presentation] あらたに開発した定量的熱刺激装置を用いたCPM評価 (2015)
  • Author(s): 今村敏克、大野由夏、大上沙央理、長坂浩、小長谷光
  • Organizer: 日本麻酔科学会 第62回学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2015-05-28
• [Presentation] 新しく開発した圧痛覚閾値測定用アルゴメーターの信頼性 (2015)
  • Author(s): 内田茂則、鈴木佐知子、大野由夏、大上沙央理、小長谷 光
  • Organizer: 日本麻酔科学会 第62回学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2015-05-28
• [Presentation] THE RELIABILITY OF NEW PRESSURE ALGOMETER IN MEASURING PRESSURE PAIN THRESHOLD IN HUMAN STUDIES (2014)
  • Author(s): Yuka Oono, Hikaru Kohase, Katsuhiro Matsumoto, Kelun Wang, Lars Arendt-Nielsen
  • Organizer: The 15th World Congress on Pain
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2014-10-06 – 2014-10-11
• [Presentation] Exteroceptive reflex parameters for different temperatures application on masseter muscle of healthy human. (2014)
  • Author(s): Atis ES, Wang K, Oono Y, Tatar Y, Lars Arendt-Nielsen.
  • Organizer: The 15th World Congress on Pain
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2014-10-06 – 2014-10-11
• [Presentation] Conditioned pain modulation in temporomandibular disorders patients. (2013)
  • Author(s): Oono Y, Wang K, Baad-Hansen L, Futarmal S, Ogami S, Matsumoto K, Fukayama H, Kohase H, Svensson P, Arendt-Nielsen L.
  • Organizer: 8th Congress of the European Federation of IASP Chapters (EFIC)
  • Place of Presentation: Florence, Italy
• [Presentation] 意図的レミフェンタニル濃度維持による静穏な全身麻酔からの覚醒 (2013)
  • Author(s): 小長谷光、市川怜那、田草川裕子、熊坂祝、大野由夏、大上沙央理、松村朋香、深山治久
  • Organizer: 第41回日本歯科麻酔学会総会・学術集会
  • Place of Presentation: 横浜