Metabolic Flexibility in non-obese patients with type 2 diabetes mellitus: meal ingestion and daily physical activity

• Project/Area Number: 25870233
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied health science; Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: The University of Electro-Communications
• Principal Investigator: OHKAWARA Kazunori 電気通信大学, 情報理工学(系)研究科, 准教授 (30631270)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 2型糖尿病 / 基質酸化 / エネルギー代謝

Outline of Final Research Achievements

There are many non-obese patients with type 2 diabetes mellitus in Japanese population however a diet therapy targeting them is not established based on scientific evidence. The purpose of this study was to investigate capacity of utilizing glucose and fat as energy sources in non-obese patients with type 2 diabetes mellitus. As results, their capacity of glucose and fat utilization could be attenuated therefor they cannot use both of fat and glucose as energy source efficiency after meal ingestion. Furthermore, spending a long time by very light activities may negatively influence insulin secretion.

Research Products

• [Journal Article] Validity and reproducibility of a novel method for time-course evaluation of diet-induced thermogenesis in a respiratory chamber. (2015)
  • Author(s): Usui C, Ando T, Ohkawara K, Miyake R, Oshima Y, Hibi M, Oishi S, Tokuyama K, Tanaka S.
  • Journal Title: Physiological Reports
  • Peer Reviewed / Open Access
• [Journal Article] 加速度計による活動量評価と身体活動増進介入への活用. (2015)
  • Author(s): 笹井浩行, 引原有輝, 岡﨑勘造, 中田由夫, 大河原一憲.
  • Journal Title: 運動疫学研究 Volume: 17（1） Pages: 6-18
  • NAID: 130007830236
  • Peer Reviewed / Open Access
• [Journal Article] ICTを用いた運動・身体活動の測定方法と健康増進への活用. (2015)
  • Author(s): 大河原一憲, 笹井浩行.
  • Journal Title: 情報処理 Volume: 56（２） Pages: 152-158
• [Journal Article] Evaluation of active video games intensity: comparison between accelerometer-based predictions and indirect calorimetric measurements (2014)
  • Author(s): 1. Tripette J, Ando T, Murakami H, Yamamoto K, Ohkawara K, Tanaka S, Miyachi M
  • Journal Title: Technology and Health Care Volume: -
  • Peer Reviewed
• [Journal Article] Prediction models discriminating between nonlocomotive and locomotive activities in children using a triaxial accelerometer with a gravity-removal physical activity classification algorithm (2014)
  • Author(s): Hikihara Y, Tanaka C, Oshima Y, Ohkawara K, Ishikawa-Takata K, Tanaka S.
  • Journal Title: PLoS One Volume: 9 Issue: 4 Pages: e94940-e94940
  • DOI: 10.1371/journal.pone.0094940
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 在住幼児の体力・運動能力と就学前の保育・教育施設内および施設外における運動・スポーツの実施状況や日常の身体活動量に関する横断的研究 (2014)
  • Author(s): 3. 田中 千晶, 引原 有輝, 安藤 貴史, 大河原 一憲, 薄井 澄誉子, 佐々木 玲子, 田中 茂穂
  • Journal Title: 体力科学 Volume: -
  • Peer Reviewed
• [Presentation] Responsiveness of physical activity evaluated with GPAQ during a weight loss intervention in overweight Japanese adults. (2015)
  • Author(s): Nakata Y, Sasai H, Tsujimoto T, Ohkawara K, Inoue S, Oka K, Tanaka S.
  • Organizer: 日本疫学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-01-21 – 2015-01-23
• [Presentation] Validity and reproducibility of a novel method for time-course evaluation of diet-induced thermogenesis in a respiratory chamber. (2014)
  • Author(s): Usui C, Ando T, Ohkawara K, Miyake R, Oshima Y, Hibi M, Oishi S, Tokuyama K, Tanaka S.
  • Organizer: 3rd international conference on Recent Advances and Controversies in the Measurement of Energy Metabolism
  • Place of Presentation: Tokyo
  • Year and Date: 2014-10-10 – 2014-10-12
• [Presentation] Evaluation of active video games intensity and methodological concerns. (2014)
  • Author(s): Tripette J, Ando T, Murakami H, Yamamoto K, Ohkawara K, Tanaka S, Miyachi M.
  • Organizer: 3rd international conference on Recent Advances and Controversies in the Measurement of Energy Metabolism
  • Place of Presentation: Tokyo
  • Year and Date: 2014-10-10 – 2014-10-12
• [Presentation] Effects of Japanese dietary pattern on body weight control and anti-aging: An interventional study. (2014)
  • Author(s): Ohkawara K, Nakamura S, Hata K, Miyashita M, Nagasawa J, Nakata Y, Oka J, Inayama T.
  • Organizer: 3rd international conference on Recent Advances and Controversies in the Measurement of Energy Metabolism
  • Place of Presentation: Tokyo
  • Year and Date: 2014-10-10 – 2014-10-12
• [Presentation] 労働者の座位時間を評価する質問紙の開発: activePALを打倒基準とした試み. (2014)
  • Author(s): 松尾知明, 笹井浩行, 大河原一憲.
  • Organizer: 日本体力医学会大会
  • Place of Presentation: 長崎
  • Year and Date: 2014-09-19 – 2014-09-21
• [Presentation] 世界標準化身体活動質問票と加速度計による中強度以上身体活動時間: Boutを考慮した比較. (2014)
  • Author(s): 6)中田由夫, 辻本健彦, 田中茂穂, 大河原一憲, 岡浩一朗, 井上茂.
  • Organizer: 日本体力医学会大会
  • Place of Presentation: 長崎
  • Year and Date: 2014-09-19 – 2014-09-21
• [Presentation] 加速度計を用いた身体活動評価における非装着時間, 採用日数, 休日の考慮による影響. (2014)
  • Author(s): 7)辻本健彦, 中田由夫, 田中茂穂, 大河原一憲, 岡浩一朗, 井上茂.
  • Organizer: 日本体力医学会大会
  • Place of Presentation: 長崎
  • Year and Date: 2014-09-19 – 2014-09-21
• [Presentation] 世界標準化身体活動質問票（GPAQ）第2版日本語版の作成 (2014)
  • Author(s): 中田由夫, 井上茂, 大河原一憲, 岡浩一朗, 小熊祐子, 高田和子, 田中茂穂, 田中千晶, 萩裕美子, 齋藤義信, 村瀬訓生
  • Organizer: 第24回日本疫学会学術総会
  • Place of Presentation: 宮城
• [Presentation] 玄米飯を主食とした日本型食生活が抗酸化力に及ぼす効果 (2014)
  • Author(s): 2. 平川和幸, 中村彩希, 秦希久子, 稲山貴代, 宮下政司, 長澤純一, 中田由夫, 岡純, 大河原一憲
  • Organizer: 第15回日本健康支援学会年次学術大会
  • Place of Presentation: 東京
• [Presentation] 質問紙で評価した身体活動ガイドライン達成者の活動レベルを加速度計で評価する (2013)
  • Author(s): 3. 中田由夫, 井上茂, 大河原一憲, 岡浩一朗, 小熊祐子, 高田和子, 田中茂穂, 田中千晶
  • Organizer: 第68回日本体力医学会大会
  • Place of Presentation: 東京
• [Presentation] 高い有酸素性能力は高脂質摂取時において1日の脂質酸化量の増加をもたらす (2013)
  • Author(s): 4. 安藤貴史, 薄井澄誉子, 大河原一憲, 三宅理江子, 朴鍾薫, 宮下政司, 江崎治, 樋口満, 田中茂穂
  • Organizer: 第68回日本体力医学会大会
  • Place of Presentation: 東京