| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Multidrug-resistant organisms become more problematic worldwide. Although vancomycin and colistin has been key drug against these infections, their nephrotoxicity limited clinical efficacy. We focused on the transporter of proximal renal tubule and analyzed the mechanism responsible for the development of renal involvement. Megalin was identified as a target molecule of the nephrotoxicity through experiments with knock-out mouse and QCM (quartz crystal microbalance). Megalin ligand antagonist was also detected. Megalin ligand antagonist reduced renal damage in mouse model, and held the promise of treating drug-induced renal impairment.
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