Antiboitics induced renal injury; explanation for the mechanism and strategy for the prevention
| Project/Area Number |
25870245
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Infectious disease medicine
Kidney internal medicine
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| Research Institution | Niigata University |
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Principal Investigator |
AOKI Nobumasa 新潟大学, 医歯学総合病院, 助教 (60646933)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | メガリン / コリスチン / バンコマイシン / 薬剤性腎障害 / シラスタチン / ゲンタマイシン / 近位尿細管上皮細胞 |
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| Outline of Final Research Achievements |
Multidrug-resistant organisms become more problematic worldwide. Although vancomycin and colistin has been key drug against these infections, their nephrotoxicity limited clinical efficacy. We focused on the transporter of proximal renal tubule and analyzed the mechanism responsible for the development of renal involvement. Megalin was identified as a target molecule of the nephrotoxicity through experiments with knock-out mouse and QCM (quartz crystal microbalance). Megalin ligand antagonist was also detected. Megalin ligand antagonist reduced renal damage in mouse model, and held the promise of treating drug-induced renal impairment.
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Report
(3 results)
Research Products
(5 results)
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[Presentation] 薬剤性腎障害とメガリン2014
Author(s)
斎藤亮彦
Organizer
日本腎臓学会東部学術大会
Place of Presentation
東京都新宿区 ベルサール新宿グランド
Year and Date
2014-10-25
Related Report
Invited
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