Elucidation of regulation mechanisms of RP105/MD-1 in obesity-induced chronic inflammation
| Project/Area Number |
25870257
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
Immunology
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| Research Institution | University of Toyama |
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Principal Investigator |
WATANABE Yasuharu 富山大学, 大学院医学薬学研究部(医学), 客員助教 (80646307)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 炎症 / 内臓脂肪組織 / 脂肪組織 / メタボリックシンドローム / 自然炎症 |
|---|
| Outline of Final Research Achievements |
The RP105/MD-1 complex expressing cells in hematopoietic cells were involved in high-fat diet-induced adipose tissue inflammation. We found that levels of soluble MD-1 in mice serum were increased by high-fat diet. Soluble MD-1 was dramatically increased by high-fat diet in visceral adipose tissue and produced from stromal vascular cells in the tissue. Soluble MD-1 was increased in co-culture of macrophages and adipocytes, suggesting that macrophages produce soluble MD-1 by the interaction with adipocytes. We identified several candidate lipids from lipid library, which interact with MD-1.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Isoliquiritigenin attenuates adipose tissue inflammation in vitro and adipose tissue fibrosis through inhibition of innate immune responses in mice.2016
Author(s)
Watanabe Y, Nagai Y, Honda H, Okamoto N, Yamamoto S, Hamashima T, Ishii Y, Tanaka M, Suganami T, Sasahara M, Miyake, K, Takatsu K.
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Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 23097-23097
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation.2014
Author(s)
Honda H., Nagai Y., Matsunaga T., Okamoto N., Watanabe Y., Tsuneyama K., Hayashi H., Fujii I., Ikutani M., Hirai Y., Muraguchi A., Takatsu K.
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Journal Title
Journal of Leukocyte Biology
Volume: 96
Issue: 6
Pages: 1087-1100
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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