| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The RP105/MD-1 complex expressing cells in hematopoietic cells were involved in high-fat diet-induced adipose tissue inflammation. We found that levels of soluble MD-1 in mice serum were increased by high-fat diet. Soluble MD-1 was dramatically increased by high-fat diet in visceral adipose tissue and produced from stromal vascular cells in the tissue. Soluble MD-1 was increased in co-culture of macrophages and adipocytes, suggesting that macrophages produce soluble MD-1 by the interaction with adipocytes. We identified several candidate lipids from lipid library, which interact with MD-1.
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