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Elucidation of regulation mechanisms of RP105/MD-1 in obesity-induced chronic inflammation

Research Project

Project/Area Number 25870257
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Metabolomics
Immunology
Research InstitutionUniversity of Toyama

Principal Investigator

WATANABE Yasuharu  富山大学, 大学院医学薬学研究部(医学), 客員助教 (80646307)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords炎症 / 内臓脂肪組織 / 脂肪組織 / メタボリックシンドローム / 自然炎症
Outline of Final Research Achievements

The RP105/MD-1 complex expressing cells in hematopoietic cells were involved in high-fat diet-induced adipose tissue inflammation. We found that levels of soluble MD-1 in mice serum were increased by high-fat diet. Soluble MD-1 was dramatically increased by high-fat diet in visceral adipose tissue and produced from stromal vascular cells in the tissue. Soluble MD-1 was increased in co-culture of macrophages and adipocytes, suggesting that macrophages produce soluble MD-1 by the interaction with adipocytes. We identified several candidate lipids from lipid library, which interact with MD-1.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (20 results)

All 2016 2015 2014 2013 Other

All Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 7 results,  Open Access: 1 results,  Acknowledgement Compliant: 3 results) Presentation (9 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Isoliquiritigenin attenuates adipose tissue inflammation in vitro and adipose tissue fibrosis through inhibition of innate immune responses in mice.2016

    • Author(s)
      Watanabe Y, Nagai Y, Honda H, Okamoto N, Yamamoto S, Hamashima T, Ishii Y, Tanaka M, Suganami T, Sasahara M, Miyake, K, Takatsu K.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 23097-23097

    • DOI

      10.1038/srep23097

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Glycyrrhetinic acid inhibits contact hypersensitivity induced by trichophytin via dectin-12016

    • Author(s)
      Tomoya Nakamura, Akiko Nishibu, Naoki Yoshida, Mitsue Yasoshima, Kazushi Anzawa, Yasuharu Watanabe, Yoshinori Nagai, Kiyoshi Takatsu, Kazuo Ogawa, Takashi Mochizuki
    • Journal Title

      Experimental Dermatology

      Volume: 25 Issue: 4 Pages: 299-304

    • DOI

      10.1111/exd.12931

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Differential requirements of MyD88 And TRIF pathways in TLR4-mediated immune responses in murine B cells.2015

    • Author(s)
      Yanagibashi T., Nagai Y., Watanabe Y., Ikutani M., Hirai Y., Takatsu K.
    • Journal Title

      Immunology Letters

      Volume: 163 Issue: 1 Pages: 22-31

    • DOI

      10.1016/j.imlet.2014.11.012

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation.2014

    • Author(s)
      Honda H., Nagai Y., Matsunaga T., Okamoto N., Watanabe Y., Tsuneyama K., Hayashi H., Fujii I., Ikutani M., Hirai Y., Muraguchi A., Takatsu K.
    • Journal Title

      Journal of Leukocyte Biology

      Volume: 96 Issue: 6 Pages: 1087-1100

    • DOI

      10.1189/jlb.3a0114-005rr

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Evaluating the role of conserved amino acids in bacterial O-oligosaccharyltransferases by in vivo, in vitro and limited proteolysis assays.2014

    • Author(s)
      Matias A Musumeci, Amirreza Faridmoayer, Yasuharu Watanabe, Mario F Feldman.
    • Journal Title

      Glycobiology

      Volume: 24(1) Issue: 1 Pages: 39-50

    • DOI

      10.1093/glycob/cwt087

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Activation and regulation of the pattern recognition receptors in obesity-induced adipose tissue inflammation and insulin resistance2013

    • Author(s)
      Yasuharu Watanabe, Yoshinori Nagai, Kiyoshi Takatsu
    • Journal Title

      Nutrients

      Volume: 5 Issue: 9 Pages: 3757-3778

    • DOI

      10.3390/nu5093757

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The TLR family protein RP105/MD-1 complex: a new player in obesity and adipose tissue inflammation2013

    • Author(s)
      Yoshinori Nagai, Yasuharu Watanabe, Kiyoshi Takatsu
    • Journal Title

      Adipocyte

      Volume: 2 Issue: 2 Pages: 61-66

    • DOI

      10.4161/adip.22929

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 甘草成分イソリクイリチゲニンはNLRP3インフラマソーム活性化を阻害し、2型糖尿病の慢性炎症を改善する2016

    • Author(s)
      7.本田裕恵, 長井良憲, 松永孝之, 岡本直樹, 渡邉康春, 常山幸一, 林宏明, 藤井勲, 平井嘉勝, 高津聖志
    • Organizer
      日本薬学会 第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] Accumulation of and increased IL-1β production by neutrophils in adipose tissue: roles of free fatty acid and leukotriene B42015

    • Author(s)
      Watanabe Y, Nagai Y, Takatsu K
    • Organizer
      第44回日本免疫学会学術集会,
    • Place of Presentation
      札幌
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 遊離脂肪酸誘発性の内臓脂肪組織炎症における好中球の機能解析2015

    • Author(s)
      渡邉康春, 長井良憲, 高津聖志
    • Organizer
      第36回日本肥満学会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] 遊離脂肪酸誘発性の内臓脂肪組織炎症モデルにおける好中球とIL-1βの機能解析2015

    • Author(s)
      長井良憲, 渡邉康春, 高津聖志
    • Organizer
      第36回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Year and Date
      2015-07-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] Adipocyte-derived free fatty acids trigger IL-1beta production by neutrophils in mouse adipose tissue2014

    • Author(s)
      Yasuharu Watanabe, Yoshinori Nagai, Koichi Tsuneyama, Kiyoshi Takatsu
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 遊離脂肪酸誘発性の内臓脂肪組織炎症における好中球とIL-1βの機能解析2014

    • Author(s)
      長井良憲, 渡邉康春, 高津聖志
    • Organizer
      第35回日本肥満学会
    • Place of Presentation
      宮崎
    • Year and Date
      2014-10-24
    • Related Report
      2014 Research-status Report
  • [Presentation] Regulatory mechanisms of Radioprotective 105/MD-1 expression in inflammatory macrophages in the adipose tissue2013

    • Author(s)
      Yasuharu Watanabe, Yoshinori Nagai, Kiyoshi Takatsu.
    • Organizer
      第78回日本インターフェロン・サイトカイン学会, 第21回マクロファージ分子細胞生物学国際シンポジウム 合同学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] メタボリック症候群における慢性炎症を制御する自然免疫シグナルの解析2013

    • Author(s)
      長井良憲, 渡邉康春, 本田裕恵, 戸邉一之, 高津聖志
    • Organizer
      第34回日本肥満学会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] β3-adrenergic receptor-mediated lipolysis of adipocytes induces accumulation of large number of neutrophils and pro-inflammatory responses in mouse adipose tissue2013

    • Author(s)
      Yasuharu Watanabe, Yoshinori Nagai, Koichi Tsuneyama, Kiyoshi Takatsu.
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Related Report
      2013 Research-status Report
  • [Book] 自然免疫系センサーによる慢性炎症制御とメタボリック症候群2015

    • Author(s)
      長井良憲, 渡邉康春, 高津聖志
    • Total Pages
      6
    • Publisher
      北隆館
    • Related Report
      2015 Annual Research Report
  • [Remarks] 富山大学大学院 医学薬学研究部(医学) 免疫バイオ・創薬探索研究講座

    • URL

      http://www.med.u-toyama.ac.jp/immbio/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 富山大学大学院医学薬学研究部(医学) 免疫バイオ・創薬探索研究講座

    • URL

      http://www.med.u-toyama.ac.jp/immbio/

    • Related Report
      2014 Research-status Report
  • [Remarks] 富山大大学院医学薬学研究部(医学)免疫バイオ・創薬探索研究講座

    • URL

      http://www.med.u-toyama.ac.jp/immbio/

    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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