Research Project
Grant-in-Aid for Young Scientists (B)
We synthesized partially carboxylated poly-L-lysine and discovered its cryoprotective property. This interesting phenomenon is characteristic of polymers with high electron charge, especially polyampholytes. We proposed that polyampholytes exert their cytoprotective action by protecting cells against stresses such as drastic changes in soluble space size and osmotic pressure during freezing by using solid-state NMR. Synthetic cryoprotectants revealed that the mechanisms related with the membrane protection properties of these polyampholytes by using liposome as a model membrane. The cryoprotective mechanisms are different from those of current available cryoprotectants. The novel findings might lead to the development of new effective cryoprotectants.
All 2015 2014 2013 Other
All Journal Article (7 results) (of which Peer Reviewed: 7 results, Acknowledgement Compliant: 2 results) Presentation (14 results) (of which Invited: 5 results) Book (1 results)
Cryobiology and Cryotechnology
Volume: 60 Pages: 99-103
110009878793
Biomaterials
Volume: 35 Issue: 24 Pages: 6508-6518
10.1016/j.biomaterials.2014.04.030
Current Nanoscience,
Volume: 10 Issue: 2 Pages: 222-226
10.2174/1573413709999131209123737
J. Phys. Chem. B
Volume: 118 Issue: 34 Pages: 10240-10249
10.1021/jp507697q
Volume: 59 Pages: 111-115
110009662025
Volume: 59 Pages: 23-28
Biomaterials Science
Volume: 3 Issue: 3 Pages: 308-317
10.1039/c3bm60261c
