Development of biomimetic fiber with molecular alignment and its application to tissue engineering
| Project/Area Number |
25870272
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
Biofunction/Bioprocess
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| Research Institution | University of Fukui |
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Principal Investigator |
Fujita Satoshi 福井大学, 工学(系)研究科(研究院), 准教授 (60504652)
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| Research Collaborator |
SUYE Shin-ichiro
MATSUMURA Kazuaki
SAKAMOTO Hiroaki
BATNYAM Onon
NISHIMOTO Shohei
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ナノファイバー / 間葉系幹細胞 / コラーゲン / エレクトロスピニング / 造血幹細胞 / 高密度培養 / 幹細胞ニッチ / ゲル / 高分子構造 / 三次元培養 / 配向制御 |
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| Outline of Final Research Achievements |
To apply nanofibers to three-dimensional tissue constructs, we have tried to develop nanofiber-based scaffolds, including the self-organization and alignment of pepitide molecules in nanofibers and the stem cell culture by using nanofiber scaffolds. We have successfully fabricated collagen gel-like fibers by exploiting core-shell nanofibers. We also developed culture sheets construct by layering alined fiber sheets and applied them to hemetopoitic stem cell culture, which is called as 'biomimetic fibers'.
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Report
(4 results)
Research Products
(23 results)
