Genome-wide analysis of epigenetic effects of endocrine disrupting chemicals on thyroid system.
| Project/Area Number |
25870296
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Risk sciences of radiation and chemicals
Life / Health / Medical informatics
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| Research Institution | Shizuoka University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 内分泌かく乱物質 / エピジェネティクス / 内分泌撹乱 |
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| Outline of Final Research Achievements |
Thyroid hormone (TH) plays an important role in various biological processes. Thyroid system is thought to be one of the important endpoints affected by several environmental chemicals. The aims of this research are: 1) to clarify the molecular mechanism of TH-TH-receptor (TR) action, and 2) to clarify the effects of environmental chemicals on the epigenetic control of TH-responsive gene expression.
T3-induced thrb gene activation is mediated by liganded TR binding to TREs in the 5' flanking and exon b regions. T3 induced the euchromatin-associated epigenetic marks in the 5' flanking and exon b regions.
Ioxynil and tetrabromobisphenol A altered T3-induced histone H3 and RNAPII post-translational modifications that are closely linked to transcriptional elongation stages of RNAPII. We detected chemical-specific and target gene-dependent effects, which may reflect the differences in action sites of the chemicals.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Morphological, biochemical, transcriptional and epigenetic responses to fasting and refeeding in intestine of Xenopus laevis.2016
Author(s)
Tamaoki, K., Okada, R., Ishihara, A., Shiojiri, N., Mochizuki, K., Goda, T., Yamauchi, K.
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Journal Title
Cell Biosci.
Volume: 6
Issue: 1
Pages: 2-2
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] The secretogranin II gene is a signal integrator of glutamate and dopamine inputs.2014
Author(s)
Iwase, K., Ishihara, A., Yoshimura, S., Andoh, Y., Kato, M., Seki, N., Matsumoto, E., Hiwasa, T., Muller, D., Fukunaga, K., and Takiguchi, M.
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Journal Title
Journal of Neurochemistry
Volume: 128
Issue: 2
Pages: 233-245
DOI
Related Report
Peer Reviewed
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