Elucidating the intracellular molecular mechanisms of cell death of cancer cells by atmospheric pressure plasma
Project/Area Number |
25870307
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Plasma electronics
Tumor biology
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Research Institution | Nagoya University |
Principal Investigator |
TANAKA Hiromasa 名古屋大学, 未来社会創造機構, 講師 (00508129)
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Co-Investigator(Renkei-kenkyūsha) |
ISHIKAWA Kenji 名古屋大学, プラズマナノ工学研究センター, 特任教授 (60417384)
NAKAMURA Kae 名古屋大学, 大学院医学系研究科, 特任講師 (10744047)
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | プラズマがん治療 / プラズマ医療 / がん / シグナル伝達 |
Outline of Final Research Achievements |
We found that plasma-irradiated medium induced apoptosis on glioblastoma brain tumor cells, and termed this medium plasma-activated medium (PAM). PAM down-regulated activities of signaling molecules in the survival and proliferation signaling network and induced reactive oxygen species (ROS) on glioblastoma to induce apoptosis. The PAM projects have brought us many collaborative works that include collaborations with departments of Obsterics and gynecology, Gastrointestinal surgery for treatments of peritoneal dissemination of ovarian cancers and gastric cancers, and Ophthalmology for treatments of age-related macular degeneration. We have published 10 papers and applied for 9 patents.
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Report
(3 results)
Research Products
(29 results)
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[Journal Article] Plasma-activated medium suppresses choroidal neovascularization in mice: a new therapeutic concept for age-related macular degeneration2015
Author(s)
F. Ye, H. Kaneko, Y. Nagasaka, R. Ijima, K. Nakamura, M. Nagaya, K. Takayama, H. Kajiyama, T. Senga, H. Tanaka, M. Mizuno, F. Kikkawa, M. Hori, and H. Terasaki
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Journal Title
Sci Rep
Volume: 5
Issue: 1
Pages: 7705-7705
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Effectiveness of plasma treatment on gastric cancer cells2014
Author(s)
K. Torii, S. Yamada, K. Nakamura, H. Tanaka, H. Kajiyama, K. Tanahashi, N. Iwata, M. Kanda, D. Kobayashi, C. Tanaka, T. Fujii, G. Nakayama, M. Koike, H. Sugimoto, S. Nomoto, A. Natsume, M. Fujiwara, M. Mizuno, M. Hori, H. Saya, Y. Kodera
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Journal Title
Gastric Cancer
Volume: -
Issue: 3
Pages: 1-9
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Direct exposure of non-equilibrium atmospheric pressure plasma confers simultaneous oxidative and ultraviolet modifications in biomolecules2014
Author(s)
Yasumasa Okazaki, Yue Wang, Hiromasa Tanaka, Masaaki Mizuno, Kae Nakamura, Hiroaki Kajiyama, Hiroyuki Kano, Koji Uchida, Fumitaka Kikkawa, Masaru Hori, Shinya Toyokuni
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Journal Title
Journal of Clinical Biochemistry and Nutrition
Volume: 55
Issue: 3
Pages: 207-215
DOI
NAID
ISSN
0912-0009, 1880-5086
Related Report
Peer Reviewed / Open Access
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[Journal Article] Plasma Medical Science for Cancer Therapy: Toward Cancer Therapy Using Nonthermal Atmospheric Pressure Plasma2014
Author(s)
Hiromasa Tanaka, Masaaki Mizuno, Kenji Ishikawa, Keigo Takeda, Kae Nakamura, Fumi Utsumi, Hiroaki Kajiyama, Hiroyuki Kano, Yasumasa Okazaki, Shinnya Toyokuni,Shoichi Maruyama, Fumitaka Kikkawa, Masaru Hori
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Journal Title
IEEE TRANSACTIONS ON PLASMA SCIENCE
Volume: 42
Issue: 12
Pages: 3760-3764
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] CANCER THERAPY USING PLASMA-ACTIVATED MEDIUM AND THE INTRACELLULAR MOLECULAR MECHANISMS2015
Author(s)
Hiromasa Tanaka, Masaaki Mizuno, Kenji Ishikawa, Keigo Takeda, Hiroshi Hashizume, Kae Nakamura, Fumi Utsumi, Hiroaki Kajiyama, Hiroyuki Kano, Yasumasa Okazaki, Shinya Toyokuni, Shoichi Maruyama,Tetsuo Adachi, Hiroki Kaneko, Hiroko Terasaki, Yasuhiro Kodera, Fumitaka Kikkawa, Masaru Hori
Organizer
The 2nd International Workshop on Plasma for Cancer Treatment
Place of Presentation
Nagoya, Japan
Year and Date
2015-03-17 – 2015-03-18
Related Report
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[Presentation] Analyses of intracellular molecular mechanisms of cancer cell death in plasma-activated solutions.2014
Author(s)
H. Tanaka, M. Mizuno, K. Ishikawa, K. Takeda, K. Nakamura, F. Utsumi, H. Kajiyama, H. Kano, Y. Okazaki, S. Toyokuni, S. Maruyama, F. Kikkawa, M. Hori
Organizer
2014 Material Research Society Fall Meeting & Exhibit
Place of Presentation
Boston, USA
Year and Date
2014-11-30 – 2014-12-05
Related Report
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[Presentation] Diagnostics of intracellular signaling systems of glioblastoma brain tumor cells treated with plasma-activated medium.2014
Author(s)
H. Tanaka, M. Mizuno, K. Ishikawa, K. Takeda, K. Nakamura, F. Utsumi, H. Kajiyama, H. Kano, Y. Okazaki, S. Toyokuni, S. Maruyama, F. Kikkawa, M. Hori
Organizer
International Workshop on Diagnostics and Modeling for Plasma Medicine
Place of Presentation
Nara, Japan
Year and Date
2014-05-23 – 2014-05-24
Related Report
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[Presentation] Signaling circuits that are affected by plasma-activated medium in brain tumor cells.2014
Author(s)
H. Tanaka, M. Mizuno, K. Ishikawa, K. Takeda, K. Nakamura, F. Utsumi, H. Kajiyama, H. Kano, Y. Okazaki, S. Toyokuni, S. Maruyama, F. Kikkawa, M. Hori
Organizer
5th International Conference on Plasma Medicine
Place of Presentation
Nara, Japan
Year and Date
2014-05-18 – 2014-05-23
Related Report
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[Presentation] Survival and proliferation signaling pathways are downregulated by plasma-activated medium in glioblastoma brain tumor cells2014
Author(s)
H. Tanaka, M. Mizuno, K. Ishikawa, K. Takeda, K. Nakamura, F. Utsumi, H. Kajiyama, H. Kano, S. Maruyama, F. Kikkawa, M. Hori
Organizer
8th International Conference on Reactive Plasmas 31st Symposium on Plasma Processings
Place of Presentation
Fukuoka, Japan
Related Report
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[Presentation] Plasma-activated medium downregulated signaling pathways that control proliferation and survival in glioblastoma brain tumor cells.2014
Author(s)
H. Tanaka, M. Mizuno, K. Ishikawa, K. Takeda, K. Nakamura, F. Utsumi, H. Kajiyama, H. Kano, S. Maruyama, F. Kikkawa, M. Hori
Organizer
6th International Symposium on Advanced Plasma Science and its Applications for Nitrides and Nanomaterials / 7th International Conference on Plasma-Nano Technology & Science
Place of Presentation
Nagoya, Japan
Related Report
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[Presentation] INTRACELLULAR MOLECULAR MECHANISMS OF APOPTOSIS IN CANCER CELLS BY PLASMA-ACTIVATED MEDIUM2014
Author(s)
Hiromasa Tanaka (Invited), Masaaki Mizuno, Kenji Ishikawa, Keigo Takeda, Kae Nakamura, Fumi Utsumi, Hiroaki Kajiyama, Hiroyuki Kano, Yasumasa Okazaki, Shinya Toyokuni, Shoichi Maruyama, Fumitaka Kikkawa, Masaru Hori
Organizer
The 1st International Workshop on Plasma for Cancer Treatment
Place of Presentation
Washington D.C., USA
Related Report
Invited
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[Presentation] Cancer therapy using atmospheric pressure plasma2013
Author(s)
Hiromasa Tanaka (Invited), Masaaki Mizuno, Kenji Ishikawa, Keigo Takeda, Kae Nakamura, Fumi Utsumi, Hiroaki Kajiyama, Hiroyuki Kano, Yasumasa Okazaki, Shinya Toyokuni, Shoichi Maruyama, Fumitaka Kikkawa, Masaru Hori
Organizer
NU Tech @ NCSU
Place of Presentation
North Carolina, USA
Related Report
Invited
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