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Development of techniqes for the oriented immobilization of bio-sensing molecules

Research Project

Project/Area Number 25870310
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Nanobioscience
Nanomaterials chemistry
Research InstitutionOsaka University (2015)
Nagoya University (2013-2014)

Principal Investigator

IIJIMA MASUMI  大阪大学, 産業科学研究所, 特任助教 (40390728)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsバイオナノカプセル / バイオセンサー / バイオセンシング / 分子整列化 / ナノバイオ
Outline of Final Research Achievements

A bio-nanocapsule (BNC) of ~30 nm that displays a tandem form of the protein A-derived immunoglobulin G (IgG) Fc-binding Z domains (designated as ZZ-BNC) has been developed for both clustering and oriented immobilization of IgGs on the solid phase of immunosensors. In this study, we applied ZZ-BNC-scaffold for both clustering and oriented immobilization of not only IgGs but also various biosensing molecules (Fc-fused receptors). We then found that ZZ-BNC could significantly enhance the sensitivity, ligand-binding capacity, and affinity of biosensors. Thus, ZZ-BNC is a unique scaffold for various biosensing molecules on biosensor surface, which could improve various biosensing technologies in a clustering and oriented immobilization manner.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (57 results)

All 2016 2015 2014 2013 Other

All Journal Article (19 results) (of which Int'l Joint Research: 10 results,  Peer Reviewed: 19 results,  Open Access: 10 results,  Acknowledgement Compliant: 5 results) Presentation (32 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results) Book (1 results) Remarks (4 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Bio-nanocapsule-based scaffold improves the sensitivity and ligand-binding capacity of mammalian receptors on the sensor chip2016

    • Author(s)
      Iijima, M., Yoshimoto, N., Niimi, T., Maturana, A.D., Kuroda, S.
    • Journal Title

      Biotechnology journal

      Volume: 印刷中 Issue: 6 Pages: 805-813

    • DOI

      10.1002/biot.201500443

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Mutational analysis of hepatitis B virus pre-S1 (9-24) fusogenic peptide2016

    • Author(s)
      Liu, Q., Somiya, M., Shimada, N., Sakamoto, W, Yoshimoto, N., Iijima, M., Tatematsu, K., Nakai, T., Okajima, T., Maruyama, A., Kuroda, S.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Scaffold protein Enigma Homolog 1 overcomes the repression of myogenesis activation by Inhibitor of DNA binding 22016

    • Author(s)
      Nakatani, M., Ito, J., Koyama, R., Iijima, M., Yoshimoto, N., Niimi, T., Kuroda, S.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Bio-nanocapsules displaying various immunoglobulins as an active targeting-based drug delivery system2016

    • Author(s)
      Kenji Tatematsu, Masumi Iijima, Nobuo Yoshimoto, Tadashi Nakai, Toshihide Okajima, Shun’ichi Kuroda
    • Journal Title

      Acta Biomaterialia

      Volume: 35 Pages: 238-247

    • DOI

      10.1016/j.actbio.2016.02.010

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Cytokine-dependent activation of the JAK-STAT pathway in Saccharomyces cerevisiae2016

    • Author(s)
      Yoshimoto, N., Ikeda, Y., Tatematsu, K., Iijima, M., Nakai, T., Okajima, T., Tanizawa, K., Kuroda, S.
    • Journal Title

      Biotechnology and Bioengineering

      Volume: 印刷中 Issue: 8 Pages: 1796-1804

    • DOI

      10.1002/bit.25948

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mapping the heparin-binding site of the osteoinductive protein NELL1 by site-directed mutagenesis.2015

    • Author(s)
      Takahashi, K., Imai, A., Iijima, M., Yoshimoto, N., Maturana, A. D., Kuroda, S., and Niimi, T.
    • Journal Title

      FEBS Letters

      Volume: 589 Issue: 24PartB Pages: 4026-4032

    • DOI

      10.1016/j.febslet.2015.11.032

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Scaffold protein enigma homolog activates CREB whereas a short splice variant prevents CREB activation in cardiomyocytes2015

    • Author(s)
      Ito J, Iijima M, Yoshimoto N, Niimi T, Kuroda S, Maturana AD
    • Journal Title

      Cellular Signaling

      Volume: 27 Issue: 12 Pages: 2425-2433

    • DOI

      10.1016/j.cellsig.2015.09.007

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Virosomes of hepatitis B virus envelope L proteins containing doxorubicin: synergistic enhancement of human liver-specific antitumor growth activity by radiotherapy2015

    • Author(s)
      Liu Q, Jung J, Somiya M, Iijima M, Yoshimoto N, Niimi T, Maturana AD, Shin SH, Jeong SY, Choi EK, Kuroda S
    • Journal Title

      International Journal of Nanomedicine

      Volume: 10 Pages: 4159-4172

    • DOI

      10.2147/ijn.s84295

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Intracellular trafficking of bio-nanocapsule-liposome complex: Identification of fusogenic activity in the pre-S1 region of hepatitis B virus surface antigen L protein2015

    • Author(s)
      Somiya M, Sasaki Y, Matsuzaki T, Liu Q, Iijima M, Yoshimoto N, Niimi T, Maturana AD, Kuroda S
    • Journal Title

      Journal of Controlled Release

      Volume: 212 Pages: 10-18

    • DOI

      10.1016/j.jconrel.2015.06.012

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] One-step scalable preparation method for non-cationic liposomes with high siRNA content2015

    • Author(s)
      Somiya M, Yamaguchi K, Liu Q, Niimi T, Maturana AD, Iijima M, Yoshimoto N, Kuroda S
    • Journal Title

      International Journal of Pharmaceutics

      Volume: 490 Issue: 1-2 Pages: 316-323

    • DOI

      10.1016/j.ijpharm.2015.05.072

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] バイオナノカプセルを用いたセンシング分子整列化技術によるバイオセンシングの高感度化2015

    • Author(s)
      飯嶋 益巳、黒田 俊一
    • Journal Title

      生物工学会誌

      Volume: 93 Pages: 1-11

    • NAID

      110009931621

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Oligomerization-induced conformational change in the C-terminal region of Nel-like molecule 1 (NELL1) protein is necessary for the efficient mediation of murine MC3T3-E1 cell adhesion and spreading2014

    • Author(s)
      Nakamura, Y., Hasebe, A., Takahashi, K., Iijima, M., Yoshimoto, N., Maturana, A. D., Ting, K., Kuroda, S., and Niimi T.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 289 Issue: 14 Pages: 9781-9794

    • DOI

      10.1074/jbc.m113.507020

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] High-throughput de novo screening of receptor agonists with an automated single-cell analysis and isolation system.2014

    • Author(s)
      Yoshimoto N, Tatematsu K, Iijima M, Niimi T, Maturana AD, Fujii I, Kondo A, Tanizawa K, Kuroda S
    • Journal Title

      Sci Rep.

      Volume: 4 Issue: 1 Pages: 4242-4242

    • DOI

      10.1038/srep04242

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cell surface-fluorescence immunosorbent assay for real-time detection of hybridomas with efficient antibody secretion at the single-cell level2013

    • Author(s)
      Kida, A.
    • Journal Title

      Analytical Chemistry

      Volume: 85 Issue: 3 Pages: 1753-1759

    • DOI

      10.1021/ac303067k

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] An automated system for high-throughput single cell-based breeding2013

    • Author(s)
      Nobuo Yoshimoto, Akiko Kida, Xu Jie, Masaya Kurokawa, Masumi Iijima, Tomoaki Niimi, Andrés D. Maturana, Itoshi Nikaido, Hiroki R. Ueda, Kenji Tatematsu, Katsuyuki Tanizawa, Akihiko Kondo, Ikuo Fujii, Shun'ichi Kuroda
    • Journal Title

      Scientific Reports

      Volume: 3 Issue: 1 Pages: 1191-1191

    • DOI

      10.1038/srep01191

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nanocapsule-based probe for evaluating the orientation of antibodies immobilized on a solid phase2013

    • Author(s)
      Iijima, M., et al. (他 4 名)
    • Journal Title

      Analyst

      Volume: 138 Issue: 12 Pages: 3470-3477

    • DOI

      10.1039/c3an00481c

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A bio-nanocapsule containing envelope protein domain III of Japanese encephalitis virus protects mice against lethal Japanese encephalitis virus infection.2013

    • Author(s)
      Miyata T, Tafuku S, Harakuni T, Tadano M, Yoshimoto N, Iijima M, Matsuo H, Matsuzaki G, Kuroda S, Arakawa T
    • Journal Title

      Microbiology and Immunology

      Volume: 57 Issue: 6 Pages: 470-477

    • DOI

      10.1111/1348-0421.12055

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bio-Nanocapsules for Signal Enhancement of Alkaline Phosphatase-Linked Immunosorbent Assays2013

    • Author(s)
      Iijima, M., Yamamoto, M., Yoshimoto, N., Niimi, T., Kuroda, S.
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 77 Issue: 4 Pages: 843-846

    • DOI

      10.1271/bbb.120760

    • NAID

      10031170729

    • ISSN
      0916-8451, 1347-6947
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] バイオナノカプセルを用いるイムノセンシング分子整列化技術2013

    • Author(s)
      飯嶋 益巳、黒田 俊一
    • Journal Title

      バイオサイエンスとインダストリー

      Volume: 71 Pages: 314-317

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Reconstituted ZZ-L particles and planar ZZ-L membrane for the oriented immobilization of Fc-fused molecules on various types of biosensors2016

    • Author(s)
      Iijima, M., Kuroda S.
    • Organizer
      Biosensors2016
    • Place of Presentation
      Gothenburg, Sweden
    • Year and Date
      2016-05-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] High efficiency penetration of antibody-immobilized nanoneedle thorough plasma membrane for in situ detection of cytoskeletal proteins in living cells2016

    • Author(s)
      Shimizu, K., Kawamura, R., Iijima, M., Kuroda, S., Fukazawa, K., Ishihara, K., Nakamura, C.
    • Organizer
      Biosensors2016
    • Place of Presentation
      Gothenburg, Sweden
    • Year and Date
      2016-05-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Detection of vimentin using antibody-modified nanoneedle and AFM to eliminate undifferentiated iPS cells2015

    • Author(s)
      Shimizu, K., Kawamura, R., Kobayashi, T., Iijima, M., Kuroda, S., Iwata, F., Fukazawa, K., Ishihara, K., Nakamura, C
    • Organizer
      Pacifichem 2015
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-12-15 – 2015-12-20
    • Related Report
      2014 Research-status Report
  • [Presentation] Detection of vimentin using antibody-modified nanoneedle and AFM to eliminate undifferentiated iPS cells2015

    • Author(s)
      Shimizu, K., Kawamura, R., Kobayashi, T., Iijima, M., Kuroda, S., Iwata, F., Fukazawa, K., Ishihara, K., Nakamura, C.
    • Organizer
      Pacifichem2015
    • Place of Presentation
      Honolulu, USA
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Bio-nanocapsule-based Scaffold for Biosensing Techniques: A Clustering and Oriented Immobilization of Sensing Molecules2015

    • Author(s)
      Iijima, M., Kuroda S.
    • Organizer
      The 19th SANKEN International Symposium
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2015-12-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] バイオナノカプセル足場分子を用いたセンシング分子整列化技術の受容体リガンド検出への応用2015

    • Author(s)
      飯嶋益巳、黒田 俊一
    • Organizer
      第67回日本生物工学会大会
    • Place of Presentation
      鹿児島
    • Year and Date
      2015-10-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] バイオナノカプセルを用いた抗炎症タンパク質MTI-IIの生体内ピンポイント送達法の開発2015

    • Author(s)
      立松健司、岡本一起、飯嶋益巳、黒田 俊一
    • Organizer
      第67回日本生物工学会大会
    • Place of Presentation
      鹿児島
    • Year and Date
      2015-10-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] ビメンチンを標的とした未分化ヒトiPS細胞の機械的分離2015

    • Author(s)
      清水桂太、川村隆三、小林 健、飯嶋益巳、黒田俊一、岩田 太、中村 史
    • Organizer
      第67回日本生物工学会大会
    • Place of Presentation
      鹿児島
    • Year and Date
      2015-10-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] Bio-nanocapsule scaffold for oriented immobilization and clustering of sensing molecules on biosensor surfaces2015

    • Author(s)
      Iijima, M., Kuroda S
    • Organizer
      4th International Conference on Bio-Sensing Technology
    • Place of Presentation
      Lisbon, Portugal
    • Year and Date
      2015-05-10 – 2015-05-13
    • Related Report
      2014 Research-status Report
  • [Presentation] エンド-β-N-アセチルグルコサミニダーゼを用いたB型肝炎ウイルス様粒子の糖鎖構造改変2015

    • Author(s)
      岡本雄太・三崎亮・飯嶋益巳・大橋貴生・黒田俊一・藤山和仁
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Research-status Report
  • [Presentation] ネスチンを標的とした神経幹細胞の機械的分離技術の開発2015

    • Author(s)
      宮崎みなみ・清水桂太・松本大亮・川村隆三・小林 健・飯嶋益巳・黒田俊一・岩田 太・中村 史
    • Organizer
      電気化学会第82回大会
    • Place of Presentation
      横浜
    • Year and Date
      2015-03-15 – 2015-03-17
    • Related Report
      2014 Research-status Report
  • [Presentation] 抗体分子の整列提示能及びクラスタリング能を有するナノキャリア「バイオナノカプセル」を用いた抗体医薬を機能向上させる新ストラテジー2014

    • Author(s)
      荒木 響子、劉 秋実、曽宮 正晴、飯嶋益巳、黒田俊一
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Research-status Report
  • [Presentation] バイオナノカプセル足場技術によるバイオセンサー表面のセンシング分子精密整列化およびクラスター化2014

    • Author(s)
      飯嶋益巳、黒田俊一
    • Organizer
      第8回バイオ関連化学シンポジウム
    • Place of Presentation
      岡山
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] バイオナノカプセル融合As16抗原による豚における抗体産生誘導2014

    • Author(s)
      松本安喜、Nguyen Thi Nga、Nguyen Thanh Lam、三好猛晴、飯嶋益巳、黒田俊一、辻 尚利
    • Organizer
      第157回日本獣医学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2014-09-09 – 2014-09-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 未分化iPS細胞分離に向けた免疫力学検出2014

    • Author(s)
      清水桂太、川村隆三、飯嶋益巳、黒田俊一、深澤今日子、石原一彦、中村史
    • Organizer
      第66回日本生物工学会大会
    • Place of Presentation
      札幌
    • Year and Date
      2014-09-09 – 2014-09-11
    • Related Report
      2014 Research-status Report
  • [Presentation] バイオナノカプセル-リポソーム複合体による抗がん剤(ドキソルビシン)のヒト肝臓由来組織への能動的送達2014

    • Author(s)
      劉 秋実、仲本拓央、曽宮正晴、飯嶋益巳、黒田俊一
    • Organizer
      第30回日本DDS学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-30 – 2014-07-31
    • Related Report
      2014 Research-status Report
  • [Presentation] バイオナノカプセルを用いた無線QCMの高感度化2014

    • Author(s)
      野井健太郎、飯嶋益巳、黒田俊一、荻博次、平尾雅彦
    • Organizer
      第14回日本蛋白質科学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-06-25 – 2014-06-27
    • Related Report
      2014 Research-status Report 2013 Research-status Report
  • [Presentation] Bio-nanocapsule scaffold for oriented immobilization and clustering of sensing molecules on biosensor surfaces2014

    • Author(s)
      Iijima, M., Kuroda, S.
    • Organizer
      Biosensors2014
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2014-05-27 – 2014-05-31
    • Related Report
      2014 Research-status Report
  • [Presentation] Mechanical cell sorting using antibody-immobilized nanoneedle array2014

    • Author(s)
      Miyazaki, M., Kawamura, R., Rao, S.R., Kobayashi, T., Iijima, M., Kuroda, S., Iwata, F., Nakamura, C.
    • Organizer
      Biosensors2014
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2014-05-27 – 2014-05-31
    • Related Report
      2014 Research-status Report 2013 Research-status Report
  • [Presentation] Enhancement of mass-detection sensitivity in wireless-electrodeless QCM biosensors by bio-nanocapsules2014

    • Author(s)
      Noi, K., Ogi, H., Iijima, M., Kuroda, S., Hirao, M.
    • Organizer
      Biosensors2014
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2014-05-27 – 2014-05-31
    • Related Report
      2014 Research-status Report
  • [Presentation] バイオナノカプセルを用いたセンシング分子整列化技術の開発2014

    • Author(s)
      飯嶋益巳、黒田俊一
    • Organizer
      名古屋大学 予防早期医療創成センター 第4回ワークショップ
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report
  • [Presentation] ナノニードルアレイを用いた細胞分離における細胞アレイの接着力制御2014

    • Author(s)
      宮崎みなみ、川村隆三、サトゥルリラマチャンドラ ラオ、小林 健、飯嶋益巳、黒田俊一、岩田 太、中村 史
    • Organizer
      日本化学会第94春季年会(2014)
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report
  • [Presentation] Enhancement of mass-detection sensitivity in wireless-electrodeless QCM biosensors by bio-nanocapsules.2014

    • Author(s)
      Noi, K., Ogi, H., Iijima, M., Kuroda, S., Hirao, M.
    • Organizer
      Biosensors2014
    • Place of Presentation
      Melbourne, Australia
    • Related Report
      2013 Research-status Report
  • [Presentation] Bio-nanocapsule scaffold for oriented immobilization and clustering of sensing molecules on biosensor surfaces.2014

    • Author(s)
      Iijima, M., Kuroda S.
    • Organizer
      Biosensors2014
    • Place of Presentation
      Melbourne, Australia
    • Related Report
      2013 Research-status Report
  • [Presentation] Bio-nanocapsules for optimizing nanostructure of biosensor surface.2013

    • Author(s)
      Iijima, M., Kuroda, S.
    • Organizer
      3rd International Conference on Bio-Sensing Technology
    • Place of Presentation
      Sitges, Spain
    • Related Report
      2013 Research-status Report
  • [Presentation] In vivo active delivery of antigens with dendritic cell-targeting Bio-nanocapsules2013

    • Author(s)
      Matsuo, H., Tomioka, M., Yoshimoto, N., Iijima, M., Kuroda S.
    • Organizer
      Vaccine Delivery and Stabilization: Improving the Reach of Vaccines
    • Place of Presentation
      Boston, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] 抗体修飾ナノニードルを用いた細胞の機械的分離2013

    • Author(s)
      宮崎みなみ、清水桂太、川村隆三、サトゥルリラマチャンドラ ラオ、小林 健、飯嶋益巳、黒田俊一、深澤今日子、石原一彦、岩田 太、中村 史
    • Organizer
      第65回日本生物工学会大会
    • Place of Presentation
      広島
    • Related Report
      2013 Research-status Report
  • [Presentation] バイオナノカプセル技術による豚回虫感染防御抗原As16の抗体産生増強効果2013

    • Author(s)
      松本安喜、Nguyen Thi Nga、Nguyen Thanh Lam、三好猛晴、飯嶋益巳、黒田俊一、辻 尚利
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜
    • Related Report
      2013 Research-status Report
  • [Presentation] 抗体修飾ナノニードルによる細胞の釣り上げ分離2013

    • Author(s)
      宮崎みなみ、川村隆三、サトゥルリラマチャンドラ ラオ、小林 健、飯嶋益巳、黒田俊一、深澤今日子、石原一彦、岩田 太、中村 史
    • Organizer
      第7回バイオ関連化学シンポジウム
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report
  • [Presentation] 細胞の機械的分離に向けたナノニードルの抗体修飾と細胞培養基板の接着制御2013

    • Author(s)
      川村隆三、宮崎みなみ、サトゥルリラマチャンドラ ラオ、小林 健、飯嶋益巳、黒田俊一、深澤今日子、石原一彦、岩田 太、中村 史
    • Organizer
      第7回バイオ関連化学シンポジウム
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report
  • [Presentation] バイオセンサー表面でセンシング分子を精密整列化するバイオナノカプセル2013

    • Author(s)
      飯嶋益巳、黒田俊一
    • Organizer
      第7回バイオ関連化学シンポジウム
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report
  • [Presentation] センシング分子ナノレベル整列化技術を用いた高機能バイオセンサーの開発2013

    • Author(s)
      飯嶋 益巳
    • Organizer
      BioJapan2013 World Business Fourum、2013年度バイオインダストリー協会賞、発酵と代謝研究奨励賞、生物素材研究開発奨励賞合同発表会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
    • Invited
  • [Book] DDSキャリア作製プロトコル集2015

    • Author(s)
      飯嶋益巳、黒田俊一
    • Total Pages
      262
    • Publisher
      CMC出版
    • Related Report
      2015 Annual Research Report
  • [Remarks] 生体分子ナノレベル整列固定化技術の開発

    • URL

      http://www.sanken.osaka-u.ac.jp/labs/smb/Biosensor.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 10倍超す高感度、低コスト効率よく…臨床検査法を実用化 阪大、免疫測定法に抗体「足場」分子

    • URL

      http://www.sankei.com/west/news/160105/wst1601050051-n1.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] BNCのバイオセンサー、イムノアッセイへの応用研究

    • URL

      http://www.agr.nagoya-u.ac.jp/~tagen/tagen/home.html

    • Related Report
      2014 Research-status Report
  • [Remarks] BNCのバイオセンサー、イムノアッセイへの応用研究

    • URL

      http://www.agr.nagoya-u.ac.jp/~tagen/tagen/home.html.html

    • Related Report
      2013 Research-status Report
  • [Patent(Industrial Property Rights)] センシング基板及びそれを用いたリガンドの測定方法2014

    • Inventor(s)
      黒田俊一、飯嶋益巳
    • Industrial Property Rights Holder
      黒田俊一、飯嶋益巳
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-064090
    • Filing Date
      2014-03-26
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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