Analysis of phospholipid-transport mechanism between mitochondria and the endoplasmic reticulum
| Project/Area Number |
25870311
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
Structural biochemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
TAMURA Yasushi 名古屋大学, 物質科学国際研究センター, 准教授 (50631876)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ミトコンドリア / リン脂質輸送 / カルジオリピン / リン脂質 |
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| Outline of Final Research Achievements |
Characteristic functions of membrane-bound structures (organelles) in cells are essential for vital activities. Proper phospholipid composition of mitochondrial membranes is required for optimal mitochondrial functions.
In this study, we identified a gene encoding a mitochondrial protein, which genetically interacts with UPS1 as a novel factor involving in phospholipid transport. In addition, by biochemical analyses using recombinant Ups1, we revealed that dynamic interactions between Ups1 and Mdm35 are important for phospholipid transport. These findings would help our understandings in mechanisms of phospholipid transport as well as mitochondrial biogenesis.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Ubiquitin is phosphorylated by PINK1 to activate parkin.2014
Author(s)
Koyano, F., Okatsu, K., Kosako, H., Tamura, Y., Go, E., Kimura, M., Kimura, Y., Tsuchiya, H., Yoshihara, H., Hirokawa, T., Endo, T., Fon. E. A., Trempe, J. F., Saeki, Y., Tanaka, K., and Matsuda, N.
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Journal Title
Nature
Volume: 510(in press)
Issue: 7503
Pages: 162-166
DOI
Related Report
Peer Reviewed
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[Journal Article] Tam41 is a CDP-diacylglycerol synthase required for cardiolipin biosynthesis in mitochondria.2013
Author(s)
Tamura, Y., Harada, Y., Nishikawa, S., Yamano, K., Kamiya, M., Shiota, T., Kuroda, T., Kuge, O., Sesaki, H., Imai, K., Tomii, K. and Endo, T.
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Journal Title
Cell Metabolism
Volume: 17
Pages: 709-718
Related Report
Peer Reviewed
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[Presentation] Tam41 is a CDP-diacylglycerol synthase for cardiolipin biosynthesis in mitochondria2013
Author(s)
Tamura, Y., Harada, Y., Nishikawa, Yamano, K. Kamiya, M., Shiota, T., Kuroda, T., Kuge, O., Sesaki, H., Imai, K., Tomii, K. and Endo T.
Organizer
The 4th International Symposium on Dynamics of Mitochondria - from Molecular Mechanisms to Physiological Functions and Disease
Place of Presentation
沖縄
Related Report
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