Inhibitory effect of natriuretic peptides on the onset of NASH from a viewpoint of lipid biology

• Project/Area Number: 25870343
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Metabolomics; Endocrinology
• Research Institution: Kyoto University
• Principal Investigator: SONOYAMA Takuhiro 京都大学, 医学(系)研究科(研究院), 助教 (70582112)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: ナトリウム利尿ペプチド / 非アルコール性脂肪肝炎 / 脂肪肝 / 質量分析 / 脂質

Outline of Final Research Achievements

Natriuretic peptides were shown to directly act on hepatocytes and to reduce hepatocellular lipid accumulation by downregulating the expression of genes associated with fatty acid synthesis and upregulating the expression of genes associated with fatty acid oxidation, from our in vivo and in vitro experiments. Moreover, it was suggested that natriuretic peptides might affect the fatty acid composition of membrane phospholipid independently of the effect on fatty acid synthesis or oxidation.
These data taken together suggest that natriuretic peptides have an inhibitory effect on both the first hit and the second hit during the onset of non-alcoholic steatohepatitis.

Research Products

• [Journal Article] Role of endogenous ACTH on circadian aldosterone rhythm in patients with primary aldosteronism (2014)
  • Author(s): Sonoyama, T., Sone, M. , Tamura, N., Honda, K., Taura, D., Kojima, K., Fukuda, Y., Kanamoto, N., Miura, M., Yasoda, A., Arai, H., Itoh, H., Nakao, K
  • Journal Title: Endocrine Connections Volume: 3 Issue: 4 Pages: 173-179
  • DOI: 10.1530/ec-14-0086
  • Peer Reviewed / Open Access
• [Journal Article] Adrenal reserve function after unilateral adrenalectomy in patients with primary aldosteronism. (2013)
  • Author(s): Honda K, Sone M, Tamura N, Sonoyama T, Taura D, Kojima K, Fukuda Y, Tanaka S, Yasuno S, Fujii T, Kinoshita H, Ariyasu H, Kanamoto N, Miura M, Yasoda A, Arai H, Ueshima K, Nakao K.
  • Journal Title: J Hypertens Volume: 31 Issue: 10 Pages: 2010-7
  • DOI: 10.1097/hjh.0b013e3283635789
  • Peer Reviewed
• [Presentation] 高脂肪食負荷による食欲制御機構破綻のメカニズム解明の試み～トランスクリプトーム解析を中心として～ (2014)
  • Author(s): 園山拓洋、田中智洋、沢田啓、井上雅文、河野裕翔、中尾一和
  • Organizer: 第35回日本肥満学会
  • Place of Presentation: 宮崎
  • Year and Date: 2014-10-24 – 2014-10-25
• [Presentation] Transcriptome Analysis of Arcuate Nucleus from Mice Fed a High-Fat Diet (2014)
  • Author(s): Takuhiro Sonoyama, Tomohiro Tanaka, Hiroshi Sawada, Masafumi Inoue, Yohei Ogino, Tingting Guo, Kazuwa Nakao
  • Organizer: 生命医薬情報学連合大会2014
  • Place of Presentation: 宮城
  • Year and Date: 2014-10-02 – 2014-10-04
• [Presentation] Inhibition of Fatty Liver and Liver Fibrosis by Brain Natriuretic Peptide (2014)
  • Author(s): Takuhiro Sonoyama, Naohisa Tamura, Kazutoshi Miyashita, Masakatsu Sone, Daisuke Taura, Mugumi Inuzuka, Kyoko Honda, Katsutoshi Kojima, and Kazuwa Nakao
  • Organizer: The Conference on Bioactive Peptides for Cell-Cell Communication 2014
  • Place of Presentation: 京都
  • Year and Date: 2014-09-10 – 2014-09-12
• [Presentation] Transcriptome Analysis of Arcuate Nucleus from Mice Fed a High-Fat Diet (2014)
  • Author(s): Takuhiro Sonoyama, Tomohiro Tanaka, Masafumi Inoue, Yohei Ogino, Tingting Guo, and Kazuwa Nakao
  • Organizer: The Conference on Bioactive Peptides for Cell-Cell Communication 2014
  • Place of Presentation: 京都
  • Year and Date: 2014-09-10 – 2014-09-12
• [Presentation] 高脂肪食負荷による食欲制御機構破綻のメカニズム解明の試み ～トランスクリプトーム解析を中心として～ (2014)
  • Author(s): 園山拓洋、田中智洋、沢田啓、井上雅文、河野裕翔、中尾一和
  • Organizer: 第32回内分泌代謝学サマーセミナー
  • Place of Presentation: 山梨
  • Year and Date: 2014-07-10 – 2014-07-12
  • Invited
• [Presentation] Differentiation of Human ES/iPS Cells into Steroid-Producing Cells (2014)
  • Author(s): Takuhiro Sonoyama, Masakatsu Sone, Kyoko Honda, Daisuke Taura, Katsutoshi Kojima, Megumi Inuzuka, Naotetsu Kanamoto, Naohisa Tamura, Kazuwa Nakao
  • Organizer: ICE/ENDO2014
  • Place of Presentation: Chicago
  • Year and Date: 2014-06-21 – 2014-06-24
• [Presentation] 高脂肪食負荷マウスの視床下部弓状核のトランスクリプトーム解析 (2014)
  • Author(s): 園山拓洋、田中智洋、沢田啓、井上雅文、河野裕翔、中尾一和
  • Organizer: 第57回日本糖尿病学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-05-22 – 2014-05-24
• [Presentation] 高脂肪食負荷マウスの視床下部弓状核のトランスクリプトーム解析 (2014)
  • Author(s): 園山拓洋、田中智洋、沢田啓、井上雅文、城孝尚、河野裕翔、中尾一和
  • Organizer: 第87回日本内分泌学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2014-04-24 – 2014-04-26
• [Presentation] 園山拓洋、田中智洋、沢田啓、井上雅文、城孝尚、河野裕翔、中尾一和 (2014)
  • Author(s): 高脂肪食負荷マウスの視床下部弓状核のトランスクリプトーム解析
  • Organizer: 第57回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪
• [Presentation] ヒトES細胞/iPS細胞のステロイド産生細胞への分化誘導法の開発 (2013)
  • Author(s): 園山 拓洋、曽根 正勝、本田 恭子、田浦 大輔、小嶋 勝利、犬塚 恵、金本 巨哲、 田村 尚久、中尾 一和
  • Organizer: 第86回日本内分泌学会学術集会
  • Place of Presentation: 仙台
• [Presentation] Significance of Adrenocorticotropin Stimulation Test in the Diagnosis of Aldosterone-Producing Adenoma (2013)
  • Author(s): Takuhiro SONOYAMA, Masakatsu SONE, Kazutoshi MIYASHITA, Naohisa TAMURA, Hiroshi ITOH, Kazuwa NAKAO
  • Organizer: ISARSH2013
  • Place of Presentation: 仙台