| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
The aim of this project is that the screening and validation of the novel target molecule based on the results of gene mutation analysis in renal cell carcinoma (RCC). Using first screening we found some epigenetic related genes as useful candidate target genes. Moreover, the shRNA for these candidate genes inhibited cell growth significantly in VHL gene mutant cells in vitro second screening, and showed same results in vivo.
These results suggested that these candidate target genes are anticipated as the novel target molecule in RCC and the screening methods used in this project is useful.
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