Regulatory mechanisms and physiological significance of stem cell migration in the adult tissues
| Project/Area Number |
25870363
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
Developmental biology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 腸上皮 / 幹細胞 / 細胞移動 / ニッチ / YAP / ephrin-Eph signaling / パネート細胞 / Eph-ephrinシグナル / 腸上皮幹細胞 / パターン形成 / Hippoシグナル伝達 / 生体内遺伝子導入法 / Eph/ephrinシグナル伝達 / Notch / EGF / noggin |
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| Outline of Final Research Achievements |
Tissue-resident stem cells are located in the specific microenvironment (niche) that supports maintenance and proliferation of these cells. In the intestinal epithelium, Paneth cells reside adjacent to intestinal stem cells, and secrete signaling molecules that promote survival and proliferation of the stem cells. To receive a sufficient amount of these molecules, intestinal stem cells migrate vigorously and form a mosaic pattern with Paneth cells. In this study, we have identified one of molecular mechanisms that regulate the migration of intestinal stem cells and have shown that the YAP-TEAD protein complex plays an important role in regulating this process. These results challenge the current view that stem cells reside statically in their niche environment and suggest that regulation of the stem cell migration should be crucial for the maintenance of tissue homeostasis.
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Report
(4 results)
Research Products
(8 results)
