| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Tissue-resident stem cells are located in the specific microenvironment (niche) that supports maintenance and proliferation of these cells. In the intestinal epithelium, Paneth cells reside adjacent to intestinal stem cells, and secrete signaling molecules that promote survival and proliferation of the stem cells. To receive a sufficient amount of these molecules, intestinal stem cells migrate vigorously and form a mosaic pattern with Paneth cells. In this study, we have identified one of molecular mechanisms that regulate the migration of intestinal stem cells and have shown that the YAP-TEAD protein complex plays an important role in regulating this process. These results challenge the current view that stem cells reside statically in their niche environment and suggest that regulation of the stem cell migration should be crucial for the maintenance of tissue homeostasis.
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