Biomolecule-responsible nanocomposite for DDS application
| Project/Area Number |
25870366
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nanomaterials chemistry
Physical pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
HASHIDA Yasuhiko 京都大学, 物質-細胞統合システム拠点, 研究員 (30512462)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | カーボンナノチューブ / ドラッグデリバリー / 放出制御 / 薬物キャリア / 酸化還元酵素 / ペプチド / ナノ材料 / 分子応答性 / 薬剤放出 |
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| Outline of Final Research Achievements |
To demonstrate the concept of drug release using oxidation-reduction reactions, the model drug-carrier conjugate was prepared and evaluated the release of the model drug. The carbon nanotubes/peptides composite and fluorescein were used as a model drug carrier and a model drug, respectively, and were conjugated via disulfide bond. This conjugate released fluorescein through the disulfide cleavage induced by bioreductive compounds such as reduced glutathione. The possibility that the drug release might be controlled by oxidoreductases was also suggested.
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Report
(3 results)
Research Products
(2 results)
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[Journal Article] Journal of Controlled Release2014
Author(s)
Hashida, Y., Tanaka, H., Zhou, S., Kawakami, S., Yamashita, F., Murakami, T., Umeyama, T., Imahori, H., Hashida, M.
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Journal Title
Photo thermal ablation of tumor cells using a single-walled carbon nanotube-peptide composite
Volume: 173
Pages: 59-66
DOI
Related Report
Peer Reviewed
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