Non-invasive quantitative in vivo optical imaging of cerebral blood flow and metabolism

• Project/Area Number: 25870370
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Brain biometrics; Neurosurgery
• Research Institution: Kyoto University
• Principal Investigator: SUZUKI Takashi 京都大学, 医学(系)研究科(研究院), 助教 (10572224)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 光生体計測 / 脳循環代謝 / 神経代謝カップリング / 赤外温度イメージング / レーザースペックル血流計 / 脳血管障害

Outline of Final Research Achievements

In order to detect quantitative brain function using brain temperature changes, we developed a new imaging system. The imaging system consists an infrared camera and laser speckle imaging to discriminate the effect of cerebral blood flow on the temperature change of the brain. Using this system, we succeeded to acquire the temperature image and the blood flow image simultaneously in the same region of rat cerebral cortex applying image processing. We measured the 2D distribution of the rat brain temperature and cerebral blood flow with these cameras. The changes of the brain temperature and cerebral blood flow were achieved using anesthetics (isoflurane and alfa-chloralose) while the body temperature was kept constant. As a result, we found that the temperature changes and the cerebral blood flow changes were not correlated. These results indicate that the brain temperature change is viable as a functional quantitative neuroimaging technique.

Research Products

• [Journal Article] Simultaneous Measurement of local Brain Temperature and Cerebral Blood Flow Change in Rat for Quantitative Function Brain Imaging (2014)
  • Author(s): Suzuki T, Oishi N, Fukuyama H.
  • Journal Title: Proceedings of the 2014 IEEE International Conference on Complex Medical Engineering Volume: 1 Pages: 214-219
  • Peer Reviewed
• [Journal Article] In vivo magnetic resonance imaging at 11.7 Tesla visualized the effects of neunatal transection of infaraorbital nerve upon primary and secondary trigeminal pathways in rats (2014)
  • Author(s): Ooi, Y., Inui-Yamamoto, C., Suzuki, T., Nakadate, H., Nagase, Y., Seiyama, A., Yoshioka, Y. and Seki, J.
  • Journal Title: Brain Research Volume: 1579 Pages: 84-92
  • DOI: 10.1016/j.brainres.2014.07.013
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Simultaneous Measurement of Local Brain Temperature and Cerebral Blood Flow Change in Rats for Quantitative Functional Brain Imaging (2014)
  • Author(s): Suzuki T, Oishi N, Fukuyama H
  • Journal Title: Proceedings of the 2014 IEEE International Conference on Complex Medical Engineering Volume: xx
• [Presentation] ラット脳温度・血流イメージングによる神経－脳循環代謝調節機構の評価 (2014)
  • Author(s): 鈴木崇士、大石直也、福山秀直
  • Organizer: 第26回日本脳循環代謝学会総会
  • Place of Presentation: 岡山
  • Year and Date: 2014-11-21
• [Presentation] Simultaneous Measurement of local Brain Temperature and Cerebral Blood Flow Change in Rat for Quantitative Function Brain Imaging (2014)
  • Author(s): Suzuki T, Oishi N, Fukuyama H.
  • Organizer: 2014 International Conference on Complex Medical Engineering
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2014-06-27
• [Presentation] Simultaneous Measurement of Local Brain Temperature and Cerebral Blood Flow Change in Rats for Quantitative Functional Brain Imaging (2014)
  • Author(s): Suzuki T, Oishi N, Fukuyama H
  • Organizer: International Conference on Complex Medical Engineering
  • Place of Presentation: Howard International House (Taipei)
• [Presentation] ラット脳血流・温度同時計測による神経‐脳循環代謝調節機構の評価 (2013)
  • Author(s): 鈴木 崇士、大石 直也、 福山 秀直
  • Organizer: 第25回日本脳循環代謝学会総会
  • Place of Presentation: 京王プラザホテル札幌（札幌）