| Project/Area Number |
25870381
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bioorganic chemistry
Chemical biology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 古細菌 / エーテル型膜脂質 / 化学プローブ / 蛍光ラベル / 脂質生物学 / ケミカルバイオロジー / 有機合成化学 / アーキア / 脂質 / 脂質プローブ / エーテル型リン脂質 |
|---|
| Outline of Final Research Achievements |
Structure of membrane lipids of Archaea significantly differs from that of Bacteria and Eukarya. In this study, we designed and synthesized archaeal membrane lipid analogs that bear a fluorescent group in order to unveil the biosynthesis and the dynamics of membrane lipids of Archaea. Detailed investigations of synthetic routes achieved a successful synthesis of a fluorescent-labeled archaetidylethanolamine derivative, as well as key synthetic intermediates that enable efficient preparation of archaeal-type fluorescent lipid probes with various polar head groups.
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