Selective treatment technique of caries by a pulsed laser with a wavelength of 5.8 micrometer

• Project/Area Number: 25870414
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical systems; Conservative dentistry
• Research Institution: Osaka University
• Principal Investigator: ISHII Katsunori 大阪大学, 工学(系)研究科(研究院), 助教 (20512073)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 低侵襲治療 / レーザー / 波長5.85μm / う蝕 / 選択的切削 / レーザー治療 / 虫歯 / 中赤外レーザー / ミニマルインターベンション

Outline of Final Research Achievements

Less-invasive treatment of caries has been investigated based on the characteristic absorption of dentin at 6μm wavelength range. A nanosecond pulsed laser with the wavelength of 5.85μm was found to be effective for selective removal of carious dentin. The ablation property of human carious dentin at the wavelength of 5.85μm was investigated based on dentin hardness. Extracted human teeth were irradiated at the average power density of 30 W/cm2. Hardness of dentin around the irradiation spot was measured. Relationship between decrease of hardness and increase of ablation depth was observed. It was indicated that hardness of dentin affected to ablation property of carious dentin.

Research Products

• [Journal Article] Selective removal of carious human dentin using a nanosecond pulsed laser operating at a wavelength of 5.85μm (2015)
  • Author(s): K. Ishii, T. Kita, K. Yoshikawa, K. Yasuo, K. Yamamoto, K. Awazu
  • Journal Title: Journal of Biomedical Optics Volume: 20 Issue: 5 Pages: 051023-051023
  • DOI: 10.1117/1.jbo.20.5.051023
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 分子振動領域の波長による疾患選択的レーザー治療 (2015)
  • Author(s): 石井克典，粟津邦男
  • Journal Title: 生産と技術 Volume: 67 Pages: 69-72
  • NAID: 40020321387
• [Journal Article] 分子振動領域の波長による疾患選択的レーザー治療 (2014)
  • Author(s): 石井克典，粟津邦男
  • Journal Title: 光アライアンス Volume: 25 Pages: 33-37
  • NAID: 40020321387
• [Journal Article] 波長5.85μmナノ秒パルスレーザーを用いたう蝕象牙質の選択的な除去；硬さと切削特性の関係 (2014)
  • Author(s): 北哲也，石井克典，吉川一志，保尾謙三，山本一世，粟津邦男
  • Journal Title: 日本レーザー歯学会誌 Volume: 25 Pages: 2-7
  • NAID: 130004565029
  • Peer Reviewed
• [Journal Article] In-vitro study about selective removal of bovine demineralized dentin using nanosecond pulsed laser at wavelengths around 5.8μm for realizing less invasive treatment of dental caries (2014)
  • Author(s): T. Kita, K. Ishii, K. Yoshikawa, K. Yasuo, K. Yamamoto, K. Awazu
  • Journal Title: Lasers in Medical Science Volume: 印刷中 Issue: 3 Pages: 961-967
  • DOI: 10.1007/s10103-013-1517-9
  • Peer Reviewed
• [Journal Article] 中赤外域におけるレーザーの医療応用の動向 (2013)
  • Author(s): 石井克典，粟津邦男
  • Journal Title: 日本赤外線学会誌 Volume: 23 (1) Pages: 64-70
  • Peer Reviewed
• [Presentation] Mid-infrared laser tissue interactions for less-invasive and selective laser treatments (2015)
  • Author(s): K. Ishii, K. Hashimura, K. Awazu
  • Organizer: The Joint Symposium of 9th International Symposium on Medical, Bio- and Nano-Electronics, and 6th International Workshop on Nanostructures & Nanoelectronics
  • Place of Presentation: Sendai (Japan)
  • Year and Date: 2015-03-02 – 2015-03-04
  • Invited
• [Presentation] Selective ablation of human carious dentin with nanosecond pulsed laser at wavelength of 5.85μm: relationship between dentin hardness and ablation depth (2014)
  • Author(s): K. Ishii, K. Yoshikawa, K. Yasuo, K. Yamamoto, K. Awazu
  • Organizer: International Conference on Laser Applications in Life Sciences 2014
  • Place of Presentation: Neu-Ulm (Germany)
  • Year and Date: 2014-06-29 – 2014-07-02
• [Presentation] 疾患選択的治療に向けた中赤外レーザによる生体組織の切除 (2014)
  • Author(s): 石井克典，橋村圭亮，粟津邦男
  • Organizer: 第81回レーザ加工学会
  • Place of Presentation: 大阪大学銀杏会館（大阪府・吹田市）
  • Year and Date: 2014-05-27 – 2014-05-28
  • Invited
• [Presentation] 波長5.85μm のナノ秒パルスレーザーを用いたヒトう蝕象牙質除去における硬さと切削深さの関係 (2014)
  • Author(s): 石井克典，北哲也，吉川一志，保尾謙三，山本一世，粟津邦男
  • Organizer: レーザー学会創立40周年記念学術講演会第34回年次大会
  • Place of Presentation: 北九州国際会議場（北九州市）
• [Presentation] Ablation of human carious dentin with a nanosecond pulsed laser at a wavelength of 5.85μm: relationship between hardness and ablation depth (2014)
  • Author(s): K. Ishii, T. Kita, K. Yoshikawa, K. Yasuo, K. Yamamoto, K. Awazu
  • Organizer: Photonics West BiOS 2014
  • Place of Presentation: The Moscone Center（サンフランシスコ）
• [Presentation] Selective excavation of demineralized dentin using a mid-infrared tunable nanosecond pulsed laser at wavelengths around 6μm (2013)
  • Author(s): K. Ishii, T. Kita, K. Yoshikawa, K. Yasuo, K. Yamamoto, K. Awazu
  • Organizer: Conference on Laser Surgery and Medicine 2013
  • Place of Presentation: パシフィコ横浜（横浜市）
• [Presentation] Selective removal of human carious dentin using a nanosecond pulsed laser with 5.8μm wavelength range (2013)
  • Author(s): T. Kita, K. Ishii, K. Yoshikawa, K. Yasuo, K. Yamamoto, K. Awazu
  • Organizer: Conference on Laser Surgery and Medicine 2013
  • Place of Presentation: パシフィコ横浜（横浜市）
• [Presentation] Selective excavation of human carious dentin using a nanosecond pulsed laser with a wavelength of 5.85μm (2013)
  • Author(s): T. Kita, K. Ishii, K. Yoshikawa, K. Yasuo, K. Yamamoto, K. Awazu
  • Organizer: European Conferences on Biomedical Optics 2013
  • Place of Presentation: International Congress Center Munich（ミュンヘン）
• [Presentation] Ablation of carious dentin with a nanosecond pulsed laser at a wavelength of 5.85 micrometer -relationship between selectivity and hardness- (2013)
  • Author(s): K. Ishii, T. Kita, K. Yoshikawa, K. Yasuo, K. Yamamoto, K. Awazu
  • Organizer: The 10th Conference on Lasers and Electro-Optics Pacific Rim 2013
  • Place of Presentation: 京都国際会議場（京都市）
• [Presentation] Ablation of human carious dentin using a pulsed laser at 5.85μｍ - relationship between ablation depth and physical properties - (2013)
  • Author(s): T. Kita, K. Ishii, K. Yoshikawa, K. Yasuo, K. Yamamoto, K. Awazu
  • Organizer: The 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Place of Presentation: 大阪国際会議場（大阪市）
• [Presentation] 波長5.85μmナノ秒パルスレーザーを用いたう蝕除去における切削深さと硬さの関係 (2013)
  • Author(s): 北哲也，石井克典，吉川一志，保尾謙三，山本一世，粟津邦男
  • Organizer: 第26回日本レーザー医学会関西支部会
  • Place of Presentation: 大阪大学中之島センター（大阪市）
• [Presentation] 波長5.85μmナノ秒パルスレーザーを用いたう蝕の選択的な除去；硬さと切削特性の関係 (2013)
  • Author(s): 北哲也，石井克典，吉川一志，保尾謙三，山本一世，粟津邦男
  • Organizer: 第25回日本レーザー歯学会総会・学術大会
  • Place of Presentation: 住友不動産 ベルサール新宿グランド（東京都新宿区）
• [Presentation] 波長5.85μm のナノ秒パルスレーザーを用いたう蝕象牙質の切削における硬さと切削深さの関係 (2013)
  • Author(s): 石井克典，北哲也，吉川一志，保尾謙三，山本一世，粟津邦男
  • Organizer: 第34回日本レーザー医学会総会
  • Place of Presentation: 国立がん研究センター中央病院（東京都中央区）
• [Presentation] レーザーによる疾患選択的治療 (2013)
  • Author(s): 石井克典
  • Organizer: 応用物理学会量子エレクトロニクス研究会「バイオ・メディカルフォトニクス：基礎と応用の最前線」
  • Place of Presentation: 上智大学軽井沢セミナーハウス（軽井沢町）
  • Invited