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Downstream target genes of a cancer-related transcription factor NAC1 in pancreatic cancer

Research Project

Project/Area Number 25870450
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Tumor biology
Research InstitutionShimane University

Principal Investigator

NISHI Takeshi  島根大学, 医学部, 特別協力研究員 (80538893)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords膵がん / がん関連転写制御因子 / NAC1 / 細胞浸潤能 / 膵癌 / 癌関連転写制御因子
Outline of Final Research Achievements

NAC1 is a transcription factor that belongs to the BTB/POZ domain family. We reported that low expression of NAC1 predicts poor prognosis for patients with pancreatic ductal adenocarcinoma. In this study, we elucidated that 1) NAC1 binds DNA through its BEN domain, 2) identification of the consensus DNA-binding sequence of NAC1, and 3) NAC1 forms a nuclear protein complex capable of modulating gene expression with an apparent molecular weight of 350-450 kDa.
To conquer pancreatic cancer, further analysis requires to find out true downstream genes of NAC1.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (12 results)

All 2015 2014 2013 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results,  Acknowledgement Compliant: 3 results) Presentation (6 results) Remarks (2 results)

  • [Journal Article] Gastric mixed adenoneuroendocrine carcinoma with thyroid transcription factor-1-positive neuroendocrine component.2015

    • Author(s)
      Yamaguchi E, Sato Y, Oe T, Nishi T, Koike M, Kitakado Y, Takubo K.
    • Journal Title

      Clin J Gastroenterol

      Volume: 8 Issue: 2 Pages: 82-87

    • DOI

      10.1007/s12328-015-0562-2

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Pancreaticoduodenectomy with total meso-pancretoduodenum excision for periampullary carcinoma.2014

    • Author(s)
      Kawabata Y, Nishi T, Harada Y, Tajima Y.
    • Journal Title

      Shimane J Med Sci

      Volume: 30 Pages: 69-76

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Safety and feasibility of a pancreaticoduodenectomy with total meso-pancreatoduodenum excision: analysis in various periampullary disorders.2014

    • Author(s)
      Kawabata Y, Nishi T, Tanaka T, Tajima Y.
    • Journal Title

      Hepatogastroenterol

      Volume: 61 Pages: 821-827

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Distal pancreatectomy utilizing a flexible stapler closure eliminates the risk of pancreas-related factors for postoperative pancreatic fistula.2013

    • Author(s)
      Kawabata Y, Nishi T, Tanaka T, Yano S, Tajima Y.
    • Journal Title

      Eur Surg Res.

      Volume: 50 Issue: 2 Pages: 71-79

    • DOI

      10.1159/000349977

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 膵癌治療における腹腔鏡の応用とその有用性2013

    • Author(s)
      髙井清江、西 健、川畑康成、木谷昭彦、比良英司、矢野誠司、田島義証
    • Organizer
      第113回日本外科学会定期学術集会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] 浸潤性膵癌切除例に対する放射線化学療法先行補助療法の治療成績2013

    • Author(s)
      西 健、川畑康成、門馬浩行、矢野誠司、田島義証
    • Organizer
      第25回肝胆膵外科学会・学術集会
    • Place of Presentation
      ホテル東日本宇都宮
    • Related Report
      2013 Research-status Report
  • [Presentation] 西 健、川畑康成、門馬浩行、木谷昭彦、髙井清江、比良英司、矢野誠司、 田島義証2013

    • Author(s)
      IPMNの治療アルゴリズム:分子型における有症状例と壁在結節の重要性
    • Organizer
      第68回日本消化器外科学会総会
    • Place of Presentation
      シーガイアコンベンションセンター
    • Related Report
      2013 Research-status Report
  • [Presentation] パネルディスカッション:Ampullary carcinomaに対する治療戦略:腫瘍発生母 地からのアプローチ2013

    • Author(s)
      川畑康成、西 健、門馬浩行、矢野誠司、田島義証
    • Organizer
      第68回日本消化器外科学会総会
    • Place of Presentation
      シーガイアコンベンションセンター
    • Related Report
      2013 Research-status Report
  • [Presentation] 浸潤性膵癌におけ転写制御因子NAC-1の低発現は予後不良の指標となる2013

    • Author(s)
      西 健、川畑康成、門馬浩行、矢野誠司、田島義証
    • Organizer
      第44回日本膵臓学会大会
    • Place of Presentation
      仙台国際センター
    • Related Report
      2013 Research-status Report
  • [Presentation] 膵癌細胞に対するTRAILとHSP70阻害剤pifithrin-μの併用効果と作用2013

    • Author(s)
      門馬浩行、原嶋奈々江、木谷昭彦、西 健、川畑康成、矢野誠司、田島義証
    • Organizer
      第44回日本膵臓学会大会
    • Place of Presentation
      仙台国際センター
    • Related Report
      2013 Research-status Report
  • [Remarks] 島根大学医学部附属病院 消化器・総合外科

    • URL

      http://www.shimane-u-dgs.jp/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 島根大学医学部附属病院 消化器・総合外科 ホームページ

    • URL

      http://www.shimane-u-dgs.jp/

    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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