Developing drug for neuropathic pain by chemically modified flavonoids targeting MEK

Research Project

Project/Area Number	25870459
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Anesthesiology Pain science
Research Institution	Okayama University
Principal Investigator	Matsuoka Yoshikazu 岡山大学, 大学病院, 助教 (20509434)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords	フラボノイド / ケルセチン / 神経障害性痛
Outline of Final Research Achievements	The aim of this study was to investigate the effect of quercetin on the neuropathic pain in the rat model. Pre-treatment of neuropathic pain by oral administrated quercetin prevented the development of pain behavior in the rat with spared nerve injury model. On the other hand, post-treatment failed to reverse the pain behavior. Immunohistochemisty and western blotting showed significant suppression of GFAP protein, a marker of astrocyte activation, in dorsal root ganglion in the treated rats. These results showed that the effect of quercetin on the neuropathic pain was mediated by the suppression of activation of satellite glial cells in dorsal root ganglia.