Developing drug for neuropathic pain by chemically modified flavonoids targeting MEK
| Project/Area Number |
25870459
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
Pain science
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | フラボノイド / ケルセチン / 神経障害性痛 |
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| Outline of Final Research Achievements |
The aim of this study was to investigate the effect of quercetin on the neuropathic pain in the rat model. Pre-treatment of neuropathic pain by oral administrated quercetin prevented the development of pain behavior in the rat with spared nerve injury model. On the other hand, post-treatment failed to reverse the pain behavior. Immunohistochemisty and western blotting showed significant suppression of GFAP protein, a marker of astrocyte activation, in dorsal root ganglion in the treated rats. These results showed that the effect of quercetin on the neuropathic pain was mediated by the suppression of activation of satellite glial cells in dorsal root ganglia.
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Report
(4 results)
Research Products
(1 results)
