| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
In this study, I examined the effect of amitriptyline (a tricyclic antidepressant) on the fibroblast growth factor (FGF) signaling in glia. We reported that the amitriptyline-induced FGF signaling activation following glial cell line derived-neurotrophic factor production is occurred by Gi/o activation (Hisaoka-Nakashima K et al., J Biol Chem 290(22): 13678-13691, 2015). Furthermore, we reported that amitriptyline increases FGF2 mRNA expression through EGR1 production in rat primary cultured astrocytes (Kajitani N et al., J Neurochem 135 (1): 27-37, 2015).
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