| Project/Area Number |
25870463
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Respiratory organ internal medicine
Experimental pathology
|
|---|
| Research Institution | Hiroshima University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 線維化 / 骨髄移植 / 肺線維症 / 間質性肺炎 / 肺障害 / 記憶免疫 / 肺傷害 |
|---|
| Outline of Final Research Achievements |
We hypothesized that in, patients with pulmonary fibrosis, there exist memory system which accelerate pulmonary fibrosis by reacting with unknown antigen. To prove this, we performed bone-marrow transplantation using healthy and bleomycin-induced pulmonary fibrosis mouse as a donor. As a result, the pulmonary fibrosis induced in recipient mice got worse when bone marrow were transplanted from donor mice with pre-established pulmonary fibrosis. In this system, monocytes lineage in donor mice with pre-established pulmonary fibrosis might play a key role.
|
