Elucidation of memory system preserved in bone marrow in pulmonary fibrosis

• Project/Area Number: 25870463
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine; Experimental pathology
• Research Institution: Hiroshima University
• Principal Investigator: NAKASHIMA Taku 広島大学, 大学病院, 病院助教 (90643792)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 線維化 / 骨髄移植 / 肺線維症 / 間質性肺炎 / 肺障害 / 記憶免疫 / 肺傷害

Outline of Final Research Achievements

We hypothesized that in, patients with pulmonary fibrosis, there exist memory system which accelerate pulmonary fibrosis by reacting with unknown antigen. To prove this, we performed bone-marrow transplantation using healthy and bleomycin-induced pulmonary fibrosis mouse as a donor. As a result, the pulmonary fibrosis induced in recipient mice got worse when bone marrow were transplanted from donor mice with pre-established pulmonary fibrosis. In this system, monocytes lineage in donor mice with pre-established pulmonary fibrosis might play a key role.

Research Products

• [Journal Article] A systematic review and meta-analysis assessing adverse event profile and tolerability of nicergoline. (2014)
  • Author(s): Fioravanti M, Nakashima T, Xu J, Garg A
  • Journal Title: BMJ Open Volume: 4 Issue: 7 Pages: e005090-e005090
  • DOI: 10.1136/bmjopen-2014-005090
  • Peer Reviewed / Open Access
• [Journal Article] Essential role of stem cell factor-c-Kit signalling pathway in bleomycin-induced pulmonary fibrosis. (2013)
  • Author(s): Ding L, Dolgachev V, Wu Z, Liu T, Nakashima T, Wu Z, Ullenbruch M, Lukacs NW, Chen Z, Phan SH.
  • Journal Title: J Pathol. Volume: 230 Issue: 2 Pages: 205-214
  • DOI: 10.1002/path.4177
  • Peer Reviewed
• [Journal Article] Lung bone marrow-derived hematopoietic progenitor cells enhance pulmonary fibrosis. (2013)
  • Author(s): Nakashima T, Liu T, Yu H, Ding L, Ullenbruch M, Hu B, Wu Z, Oguro H, Phan SH.
  • Journal Title: Am J Respir Crit Care Med. Volume: 188 Issue: 8 Pages: 976-984
  • DOI: 10.1164/rccm.201303-0479oc
  • Peer Reviewed
• [Presentation] ブレオマイシン肺線維症モデルにおける骨髄樹状細胞の役割 (2014)
  • Author(s): 中島 拓, 服部 登, 益田 武, 岩本博志, 藤高一慶, 春田吉則, 村井 博, 河野修
  • Organizer: 第17回間質性肺炎細胞分子病態研究会
  • Place of Presentation: 東京
  • Year and Date: 2014-08-23
• [Presentation] クリゾチニブ投与により制御可能であった癌性心膜炎の1例 (2014)
  • Author(s): 大崎慶子，中島 拓，山口覚博，益田 武，岩本博志，藤高一慶，春田吉則，村井 博，服部 登，河野修興
  • Organizer: 第51回日本呼吸器学会中国・四国地方会
  • Place of Presentation: 米子
  • Year and Date: 2014-07-12
• [Presentation] アンギオテンシン変換酵素阻害薬による嚥下改善作用は女性でより顕著である (2014)
  • Author(s): 中島 拓，服部 登，中増昭久，沖本真史，柳田実郎，岩本博志，石川暢久，藤
  • Organizer: 第54回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-25 – 2014-04-27
• [Presentation] 肺線維症と骨髄由来細胞 (2013)
  • Author(s): 中島 拓
  • Organizer: 第53回日本呼吸器学会総会
  • Place of Presentation: 東京
  • Invited
• [Presentation] イレウスを契機に診断された肺浸潤性粘液腺癌の一例 (2013)
  • Author(s): 稲田修吾, 中島 拓, 中増昭久, 坂本信二郎, 岩本博志, 石川暢久, 藤高一慶, 濱田泰伸, 春田吉則, 村井 博, 服部 登, 河野修興
  • Organizer: 内科学会中国地方会
  • Place of Presentation: 岡山
• [Book] Respiratory Medical Research (2014)
  • Author(s): 中島拓，服部登，河野修興
  • Total Pages: 65
  • Publisher: 先端医学社
• [Book] 呼吸器内科 (2014)
  • Author(s): 中島 拓
  • Total Pages: 6
  • Publisher: 科学評論社
• [Book] びまん性肺疾患と特発性間質性肺炎 (2014)
  • Author(s): 中島 拓、 服部 登、河野 修興
  • Total Pages: 8
  • Publisher: 医薬ジャーナル社
• [Book] 日本胸部臨床 (2013)
  • Author(s): 中島 拓、 服部 登
  • Total Pages: 9
  • Publisher: 克誠堂
• [Remarks] 肺線維症における骨髄由来細胞の役割
  • URL: http://scatalog.hiroshima-u.ac.jp/files/ebook/results2014-1/_SWF_Window.html?pagecode=137